Dietary Approach in Familial Hypercholesterolemia
Introduction: Familial hypercholesterolemia (FH) is a genetic disorder that remains underdiagnosed and undertreated. It is characterized by high levels of low-density lipoprotein cholesterol (LDL-C), which leads to an increased cardiovascular disease risk. Pharmacotherapy of FH is based on high-dose...
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MDPI AG
2025-01-01
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| Series: | Cardiogenetics |
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| Online Access: | https://www.mdpi.com/2035-8148/15/1/1 |
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| author | Joanna Popiolek-Kalisz Klaudia Salamon Michal Mazur Klaudia Mikolajczyk Grzegorz Kalisz |
| author_facet | Joanna Popiolek-Kalisz Klaudia Salamon Michal Mazur Klaudia Mikolajczyk Grzegorz Kalisz |
| author_sort | Joanna Popiolek-Kalisz |
| collection | DOAJ |
| description | Introduction: Familial hypercholesterolemia (FH) is a genetic disorder that remains underdiagnosed and undertreated. It is characterized by high levels of low-density lipoprotein cholesterol (LDL-C), which leads to an increased cardiovascular disease risk. Pharmacotherapy of FH is based on high-dose statin therapy, often combined with ezetimibe and proprotein convertase subtilisin/kexin 9 inhibitors. The dietary approach is an important and supportive part of FH management. Methods: This review aimed to present the available evidence on dietary strategies in FH patients. The analyzed aspects included macronutrients such as fat and carbohydrate intake, as well as the role of dietary fiber, nutraceuticals (omega-3, beta-glucan, phytosterols, and red yeast fermented rice extract), and overall dietary models. Results and Conclusions: Based on the available data, the Mediterranean diet is a dietary model advised in cardiovascular prevention, including patients with FH. Regarding detailed recommendations, the current state of knowledge indicates dietary fat and saturated fatty acids intake limitation as an advised strategy. Supplementation of phytosterols and fiber can be also helpful in FH. |
| format | Article |
| id | doaj-art-efa5851824604485b14561bbfae0953f |
| institution | OA Journals |
| issn | 2035-8253 2035-8148 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cardiogenetics |
| spelling | doaj-art-efa5851824604485b14561bbfae0953f2025-08-20T02:11:18ZengMDPI AGCardiogenetics2035-82532035-81482025-01-01151110.3390/cardiogenetics15010001Dietary Approach in Familial HypercholesterolemiaJoanna Popiolek-Kalisz0Klaudia Salamon1Michal Mazur2Klaudia Mikolajczyk3Grzegorz Kalisz4Clinical Dietetics Unit, Medical University of Lublin, 20-093 Lublin, PolandClinical Dietetics Unit, Medical University of Lublin, 20-093 Lublin, PolandClinical Dietetics Unit, Medical University of Lublin, 20-093 Lublin, PolandClinical Dietetics Unit, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Bioanalytics, Medical University of Lublin, 20-059 Lublin, PolandIntroduction: Familial hypercholesterolemia (FH) is a genetic disorder that remains underdiagnosed and undertreated. It is characterized by high levels of low-density lipoprotein cholesterol (LDL-C), which leads to an increased cardiovascular disease risk. Pharmacotherapy of FH is based on high-dose statin therapy, often combined with ezetimibe and proprotein convertase subtilisin/kexin 9 inhibitors. The dietary approach is an important and supportive part of FH management. Methods: This review aimed to present the available evidence on dietary strategies in FH patients. The analyzed aspects included macronutrients such as fat and carbohydrate intake, as well as the role of dietary fiber, nutraceuticals (omega-3, beta-glucan, phytosterols, and red yeast fermented rice extract), and overall dietary models. Results and Conclusions: Based on the available data, the Mediterranean diet is a dietary model advised in cardiovascular prevention, including patients with FH. Regarding detailed recommendations, the current state of knowledge indicates dietary fat and saturated fatty acids intake limitation as an advised strategy. Supplementation of phytosterols and fiber can be also helpful in FH.https://www.mdpi.com/2035-8148/15/1/1familial hypercholesterolemianutritiondietdyslipidemialipidsfiber |
| spellingShingle | Joanna Popiolek-Kalisz Klaudia Salamon Michal Mazur Klaudia Mikolajczyk Grzegorz Kalisz Dietary Approach in Familial Hypercholesterolemia Cardiogenetics familial hypercholesterolemia nutrition diet dyslipidemia lipids fiber |
| title | Dietary Approach in Familial Hypercholesterolemia |
| title_full | Dietary Approach in Familial Hypercholesterolemia |
| title_fullStr | Dietary Approach in Familial Hypercholesterolemia |
| title_full_unstemmed | Dietary Approach in Familial Hypercholesterolemia |
| title_short | Dietary Approach in Familial Hypercholesterolemia |
| title_sort | dietary approach in familial hypercholesterolemia |
| topic | familial hypercholesterolemia nutrition diet dyslipidemia lipids fiber |
| url | https://www.mdpi.com/2035-8148/15/1/1 |
| work_keys_str_mv | AT joannapopiolekkalisz dietaryapproachinfamilialhypercholesterolemia AT klaudiasalamon dietaryapproachinfamilialhypercholesterolemia AT michalmazur dietaryapproachinfamilialhypercholesterolemia AT klaudiamikolajczyk dietaryapproachinfamilialhypercholesterolemia AT grzegorzkalisz dietaryapproachinfamilialhypercholesterolemia |