Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort Study
<b>Background</b>: The sFlt-1/PlGF ratio has proven predictive value in diagnosing preeclampsia. Referring to a study from 18 American perinatal centers, we present results from 2 European centers showing the significant value of those markers in predicting severe perinatal outcomes in h...
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2025-03-01
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| author | Magdalena Bednarek-Jędrzejek Katarzyna Maksym Stepan Feduniw Slagjana Simeonova Krstevska Igor Samardziski Tomasz Góra Michał Ciebiera Adrianna Zahorowska Katarzyna Pruś Sylwia Dzidek Hanna Jasiak-Jóźwik Martyna Drzycimska Ewa Kwiatkowska Andrzej Torbé Sebastian Kwiatkowski |
| author_facet | Magdalena Bednarek-Jędrzejek Katarzyna Maksym Stepan Feduniw Slagjana Simeonova Krstevska Igor Samardziski Tomasz Góra Michał Ciebiera Adrianna Zahorowska Katarzyna Pruś Sylwia Dzidek Hanna Jasiak-Jóźwik Martyna Drzycimska Ewa Kwiatkowska Andrzej Torbé Sebastian Kwiatkowski |
| author_sort | Magdalena Bednarek-Jędrzejek |
| collection | DOAJ |
| description | <b>Background</b>: The sFlt-1/PlGF ratio has proven predictive value in diagnosing preeclampsia. Referring to a study from 18 American perinatal centers, we present results from 2 European centers showing the significant value of those markers in predicting severe perinatal outcomes in hypertensive disorders of pregnancy. <b>Methods</b>: A total of 1630 patients with suspected or confirmed placental insufficiency, hospitalized in two tertiary perinatal centers in Poland and Macedonia, were assessed for their sFlt-1/PlGF ratio. Due to incomplete data, perinatal outcomes were only obtained for 1196 patients. They were sorted into two groups according to the value of the sFlt-1/PlGF ratio (<40 and ≥40). The aim of this study was to predict adverse perinatal outcomes in terms of days to delivery, gestational age, birth weight, and cord blood pH. <b>Results</b>: The strongest negative correlation was observed between the index values and the number of days until delivery (R = −0.48; <i>p</i> < 0.001). In a group of patients with an index value of ≥40, the AUC was 0.9955 (95% CI: 0.9913 to 0.9996), with a sensitivity of 52%, a specificity of 78%, a positive predictive value of 77%, and a negative predictive value of 53%. For patients who were tested before 37 weeks of gestation, 66% of women with a ratio of ≥40 delivered within 7 days of the test, and 80% of those with a ratio of <40 delivered more than 7 days after the test, with a sensitivity of 68%, a specificity of 79%, a positive predictive value of 66%, and a negative predictive value of 80%. <b>Conclusions</b>: In women with hypertensive disorders, the sFlt-1/PlGF ratio can be used to predict the time to delivery. A cut-off of 40 is very useful in predicting severe perinatal outcomes. |
| format | Article |
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| spelling | doaj-art-efa50237af19401d8424130ae2f33e142025-08-20T02:17:00ZengMDPI AGDiagnostics2075-44182025-03-0115779910.3390/diagnostics15070799Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort StudyMagdalena Bednarek-Jędrzejek0Katarzyna Maksym1Stepan Feduniw2Slagjana Simeonova Krstevska3Igor Samardziski4Tomasz Góra5Michał Ciebiera6Adrianna Zahorowska7Katarzyna Pruś8Sylwia Dzidek9Hanna Jasiak-Jóźwik10Martyna Drzycimska11Ewa Kwiatkowska12Andrzej Torbé13Sebastian Kwiatkowski14Department of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, PolandEGA Institute for Women’s Health, University College London, London WC1E 7HB, UKDepartment of Gynecology, University Hospital of Zurich, 8091 Zurich, SwitzerlandMedical Faculty, University Clinic for Gynecology and Obstetrics, 1000 Skopje, North MacedoniaMedical Faculty, University Clinic for Gynecology and Obstetrics, 1000 Skopje, North MacedoniaClinical Department of Gynecology and Obstetrics, Municipal Hospital, John Paul II, 35-241 Rzeszów, PolandSecond Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 00-189 Warsaw, PolandDepartment of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Gynecology and Obstetrics, Pomeranian Medical University, 70-111 Szczecin, Poland<b>Background</b>: The sFlt-1/PlGF ratio has proven predictive value in diagnosing preeclampsia. Referring to a study from 18 American perinatal centers, we present results from 2 European centers showing the significant value of those markers in predicting severe perinatal outcomes in hypertensive disorders of pregnancy. <b>Methods</b>: A total of 1630 patients with suspected or confirmed placental insufficiency, hospitalized in two tertiary perinatal centers in Poland and Macedonia, were assessed for their sFlt-1/PlGF ratio. Due to incomplete data, perinatal outcomes were only obtained for 1196 patients. They were sorted into two groups according to the value of the sFlt-1/PlGF ratio (<40 and ≥40). The aim of this study was to predict adverse perinatal outcomes in terms of days to delivery, gestational age, birth weight, and cord blood pH. <b>Results</b>: The strongest negative correlation was observed between the index values and the number of days until delivery (R = −0.48; <i>p</i> < 0.001). In a group of patients with an index value of ≥40, the AUC was 0.9955 (95% CI: 0.9913 to 0.9996), with a sensitivity of 52%, a specificity of 78%, a positive predictive value of 77%, and a negative predictive value of 53%. For patients who were tested before 37 weeks of gestation, 66% of women with a ratio of ≥40 delivered within 7 days of the test, and 80% of those with a ratio of <40 delivered more than 7 days after the test, with a sensitivity of 68%, a specificity of 79%, a positive predictive value of 66%, and a negative predictive value of 80%. <b>Conclusions</b>: In women with hypertensive disorders, the sFlt-1/PlGF ratio can be used to predict the time to delivery. A cut-off of 40 is very useful in predicting severe perinatal outcomes.https://www.mdpi.com/2075-4418/15/7/799preeclampsiaangiogenic biomarkersperinatal outcomestime to deliverysFlt-1PlGF |
| spellingShingle | Magdalena Bednarek-Jędrzejek Katarzyna Maksym Stepan Feduniw Slagjana Simeonova Krstevska Igor Samardziski Tomasz Góra Michał Ciebiera Adrianna Zahorowska Katarzyna Pruś Sylwia Dzidek Hanna Jasiak-Jóźwik Martyna Drzycimska Ewa Kwiatkowska Andrzej Torbé Sebastian Kwiatkowski Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort Study Diagnostics preeclampsia angiogenic biomarkers perinatal outcomes time to delivery sFlt-1 PlGF |
| title | Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort Study |
| title_full | Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort Study |
| title_fullStr | Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort Study |
| title_full_unstemmed | Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort Study |
| title_short | Angiogenic Biomarkers: Are They Good Tools to Predict Perinatal Outcomes in Hypertensive Disorders of Pregnancy? A Retrospective Cohort Study |
| title_sort | angiogenic biomarkers are they good tools to predict perinatal outcomes in hypertensive disorders of pregnancy a retrospective cohort study |
| topic | preeclampsia angiogenic biomarkers perinatal outcomes time to delivery sFlt-1 PlGF |
| url | https://www.mdpi.com/2075-4418/15/7/799 |
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