Synthesis and In Silico Evaluation of GABA, Pregabalin and Baclofen <i>N</i>-Heterocyclic Analogues as GABA<sub>B</sub> Receptor Agonists

Synthesis and In Silico Evaluation of GABA, Pregabalin and Baclofen <i>N</i>-Heterocyclic Analogues as GABA<sub>B</sub> Receptor Agonists

<i>γ</i>-amino butyric acid (GABA) is an inhibitory neurotransmitter whose deficiency has been associated with various neurological disorders. However, its low liposolubility limits its use as a supplement. Thus, multiple investigations have focused on searching for lipophilic GABA analo...

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Bibliographic Details
Main Authors: Zuleyma Martínez-Campos, Luis Eduardo Hernandez-Dominguez, Fatima Romero-Rivera, Diana López-López, María Vicky Corona-González, Susana T. López-Cortina, Francisco José Palacios-Can, Rodrigo Said Razo-Hernández, Mario Fernández-Zertuche
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Organics
Subjects:
GABA<sub>B</sub>
Baclofen analogues
molecular docking
QSAR
molecular similarity
Online Access:https://www.mdpi.com/2673-401X/6/2/13
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