Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic
Mpox, formerly known as monkeypox, is a zoonotic virus of the Orthopoxvirus genus, with recent outbreaks of Clade I and Ib in Central Africa presenting a considerable global health threat. This study reviews current Mpox immunization approaches, focusing on the MVA-BN, LC16-KMB, and OrthopoxVac vacc...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Infectious Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772431X2500005X |
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| author | Deepak Kumar Rishabha Malviya Shriyansh Srivastava Sathvik Belagodu Sridhar Sirajunisa Talath Javedh Shareef Bhupendra G. Prajapati |
| author_facet | Deepak Kumar Rishabha Malviya Shriyansh Srivastava Sathvik Belagodu Sridhar Sirajunisa Talath Javedh Shareef Bhupendra G. Prajapati |
| author_sort | Deepak Kumar |
| collection | DOAJ |
| description | Mpox, formerly known as monkeypox, is a zoonotic virus of the Orthopoxvirus genus, with recent outbreaks of Clade I and Ib in Central Africa presenting a considerable global health threat. This study reviews current Mpox immunization approaches, focusing on the MVA-BN, LC16-KMB, and OrthopoxVac vaccines. MVA-BN vaccination has been successful in lowering infection risks, particularly in high-risk individuals and is widely used in the USA. LC16-KMB is recommended by the World Health Organization for prevention in afflicted regions. OrthopoxVac, a newer vaccination authorized in Russia, provides wide protection. Adapting vaccination approaches based on epidemiology in particular areas is critical for minimizing Mpox outbreaks. |
| format | Article |
| id | doaj-art-ef9fc8661f724358bf5b153a36903e28 |
| institution | DOAJ |
| issn | 2772-431X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infectious Medicine |
| spelling | doaj-art-ef9fc8661f724358bf5b153a36903e282025-08-20T03:01:11ZengElsevierInfectious Medicine2772-431X2025-03-014110016610.1016/j.imj.2025.100166Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemicDeepak Kumar0Rishabha Malviya1Shriyansh Srivastava2Sathvik Belagodu Sridhar3Sirajunisa Talath4Javedh Shareef5Bhupendra G. Prajapati6Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, IndiaDepartment of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India; Galgotias Multi-Disciplinary Research & Development Cell (G-MRDC), Galgotias University, Greater Noida-201308, U.P., India; Corresponding author.Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida 203201, India; Corresponding author.RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras al Khaimah 11172, United Arab EmiratesRAK College of Pharmacy, RAK Medical & Health Sciences University, Ras al Khaimah 11172, United Arab EmiratesRAK College of Pharmacy, RAK Medical & Health Sciences University, Ras al Khaimah 11172, United Arab EmiratesDepartment of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana 384012, IndiaMpox, formerly known as monkeypox, is a zoonotic virus of the Orthopoxvirus genus, with recent outbreaks of Clade I and Ib in Central Africa presenting a considerable global health threat. This study reviews current Mpox immunization approaches, focusing on the MVA-BN, LC16-KMB, and OrthopoxVac vaccines. MVA-BN vaccination has been successful in lowering infection risks, particularly in high-risk individuals and is widely used in the USA. LC16-KMB is recommended by the World Health Organization for prevention in afflicted regions. OrthopoxVac, a newer vaccination authorized in Russia, provides wide protection. Adapting vaccination approaches based on epidemiology in particular areas is critical for minimizing Mpox outbreaks.http://www.sciencedirect.com/science/article/pii/S2772431X2500005XOrthopoxvirusClade IbMVA-BNLC16-KMBOrthopoxVacGlobal outbreak |
| spellingShingle | Deepak Kumar Rishabha Malviya Shriyansh Srivastava Sathvik Belagodu Sridhar Sirajunisa Talath Javedh Shareef Bhupendra G. Prajapati Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic Infectious Medicine Orthopoxvirus Clade Ib MVA-BN LC16-KMB OrthopoxVac Global outbreak |
| title | Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic |
| title_full | Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic |
| title_fullStr | Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic |
| title_full_unstemmed | Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic |
| title_short | Personalized immunization against Mpox Clades I and Ib: Strategies to combat the emerging epidemic |
| title_sort | personalized immunization against mpox clades i and ib strategies to combat the emerging epidemic |
| topic | Orthopoxvirus Clade Ib MVA-BN LC16-KMB OrthopoxVac Global outbreak |
| url | http://www.sciencedirect.com/science/article/pii/S2772431X2500005X |
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