High‐throughput sequencing for biology and medicine
Abstract Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology...
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| Format: | Article |
| Language: | English |
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Springer Nature
2013-01-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2012.61 |
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| _version_ | 1849235661944520704 |
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| author | Wendy Weijia Soon Manoj Hariharan Michael P Snyder |
| author_facet | Wendy Weijia Soon Manoj Hariharan Michael P Snyder |
| author_sort | Wendy Weijia Soon |
| collection | DOAJ |
| description | Abstract Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medicine, often allowing researchers to address important biological questions that were not possible before. In this review, we discuss these innovative new approaches—including ever finer analyses of transcriptome dynamics, genome structure and genomic variation—and provide an overview of the new insights into complex biological systems catalyzed by these technologies. We also assess the impact of genotyping, genome sequencing and personal omics profiling on medical applications, including diagnosis and disease monitoring. Finally, we review recent developments in single‐cell sequencing, and conclude with a discussion of possible future advances and obstacles for sequencing in biology and health. |
| format | Article |
| id | doaj-art-ef9d1cd50faa4201bdb58f8258b3bea7 |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-ef9d1cd50faa4201bdb58f8258b3bea72025-08-20T04:02:44ZengSpringer NatureMolecular Systems Biology1744-42922013-01-019111410.1038/msb.2012.61High‐throughput sequencing for biology and medicineWendy Weijia Soon0Manoj Hariharan1Michael P Snyder2Department of Genetics, Stanford University School of MedicineDepartment of Genetics, Stanford University School of MedicineDepartment of Genetics, Stanford University School of MedicineAbstract Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medicine, often allowing researchers to address important biological questions that were not possible before. In this review, we discuss these innovative new approaches—including ever finer analyses of transcriptome dynamics, genome structure and genomic variation—and provide an overview of the new insights into complex biological systems catalyzed by these technologies. We also assess the impact of genotyping, genome sequencing and personal omics profiling on medical applications, including diagnosis and disease monitoring. Finally, we review recent developments in single‐cell sequencing, and conclude with a discussion of possible future advances and obstacles for sequencing in biology and health.https://doi.org/10.1038/msb.2012.61biologyhigh‐throughputmedicinesequencingtechnologies |
| spellingShingle | Wendy Weijia Soon Manoj Hariharan Michael P Snyder High‐throughput sequencing for biology and medicine Molecular Systems Biology biology high‐throughput medicine sequencing technologies |
| title | High‐throughput sequencing for biology and medicine |
| title_full | High‐throughput sequencing for biology and medicine |
| title_fullStr | High‐throughput sequencing for biology and medicine |
| title_full_unstemmed | High‐throughput sequencing for biology and medicine |
| title_short | High‐throughput sequencing for biology and medicine |
| title_sort | high throughput sequencing for biology and medicine |
| topic | biology high‐throughput medicine sequencing technologies |
| url | https://doi.org/10.1038/msb.2012.61 |
| work_keys_str_mv | AT wendyweijiasoon highthroughputsequencingforbiologyandmedicine AT manojhariharan highthroughputsequencingforbiologyandmedicine AT michaelpsnyder highthroughputsequencingforbiologyandmedicine |