Why PD-L1 expression varies between studies of lung cancer: results from a Bayesian meta-analysis

Why PD-L1 expression varies between studies of lung cancer: results from a Bayesian meta-analysis

Abstract PD-L1 expression is an important biomarker for the management of non-small cell lung cancer (NSCLC) but has been highly heterogeneous across studies. We developed a statistical model to reconcile conflicting estimates of PD-L1 prevalence by accounting for between-study variation in test sen...

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Bibliographic Details
Main Authors: Preston Ngo, Wendy A. Cooper, Stephen Wade, Kwun M. Fong, Karen Canfell, Deme Karikios, Marianne Weber
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
PD-L1
Immunohistochemistry
Immunotherapy
Biomarkers
Non-small cell lung cancer
Online Access:https://doi.org/10.1038/s41598-024-80301-9
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