The multifaceted roles of E3 ubiquitin ligases in osteoarthritis
Osteoarthritis (OA) is the most widespread joint disorder worldwide. It is a major cause of lower limb mobility issues in the elderly. With the ongoing aging of the global population and the increasing prevalence of obesity, the disease burden associated with OA is expected to rise significantly. E3...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1665313/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849229204014497792 |
|---|---|
| author | Zheng Jin Zhenhua Zhu Jun Chen Xiaopeng Jing Jie Tan Ji Zeng |
| author_facet | Zheng Jin Zhenhua Zhu Jun Chen Xiaopeng Jing Jie Tan Ji Zeng |
| author_sort | Zheng Jin |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most widespread joint disorder worldwide. It is a major cause of lower limb mobility issues in the elderly. With the ongoing aging of the global population and the increasing prevalence of obesity, the disease burden associated with OA is expected to rise significantly. E3 ubiquitin ligases (E3s) play a crucial role in protein ubiquitination. They identify specific substrates and attach ubiquitin molecules to substrates, thus modulating protein stability, function, and cellular localization. E3s can be classified into three main types: RING-, HECT-, and RBR-type E3s. Growing evidence indicates that E3s affect OA by regulating the degradation of extracellular matrix (ECM) proteins and inflammatory responses. This review highlights the functions and underlying mechanisms of E3s in OA, aiming to provide new therapeutic insights for the treatment of OA. |
| format | Article |
| id | doaj-art-ef94857423f74cdea37dd7cd9b9a533a |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-ef94857423f74cdea37dd7cd9b9a533a2025-08-22T05:27:01ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-08-011310.3389/fcell.2025.16653131665313The multifaceted roles of E3 ubiquitin ligases in osteoarthritisZheng Jin0Zhenhua Zhu1Jun Chen2Xiaopeng Jing3Jie Tan4Ji Zeng5Department of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, ChinaDepartment of Joint Surgery, Wuhan Fourth Hospital, Wuhan, ChinaOrthopedic Department, Wuhan Fourth Hospital, Wuhan, ChinaDepartment of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, ChinaOrthopedic Laboratory, Orthopedic Department & Hubei Sports Medicine Center, Wuhan Fourth Hospital, Wuhan, ChinaDepartment of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, ChinaOsteoarthritis (OA) is the most widespread joint disorder worldwide. It is a major cause of lower limb mobility issues in the elderly. With the ongoing aging of the global population and the increasing prevalence of obesity, the disease burden associated with OA is expected to rise significantly. E3 ubiquitin ligases (E3s) play a crucial role in protein ubiquitination. They identify specific substrates and attach ubiquitin molecules to substrates, thus modulating protein stability, function, and cellular localization. E3s can be classified into three main types: RING-, HECT-, and RBR-type E3s. Growing evidence indicates that E3s affect OA by regulating the degradation of extracellular matrix (ECM) proteins and inflammatory responses. This review highlights the functions and underlying mechanisms of E3s in OA, aiming to provide new therapeutic insights for the treatment of OA.https://www.frontiersin.org/articles/10.3389/fcell.2025.1665313/fullosteoarthritisE3 ubiquitin ligasesubiquitinationmechanismstreatments |
| spellingShingle | Zheng Jin Zhenhua Zhu Jun Chen Xiaopeng Jing Jie Tan Ji Zeng The multifaceted roles of E3 ubiquitin ligases in osteoarthritis Frontiers in Cell and Developmental Biology osteoarthritis E3 ubiquitin ligases ubiquitination mechanisms treatments |
| title | The multifaceted roles of E3 ubiquitin ligases in osteoarthritis |
| title_full | The multifaceted roles of E3 ubiquitin ligases in osteoarthritis |
| title_fullStr | The multifaceted roles of E3 ubiquitin ligases in osteoarthritis |
| title_full_unstemmed | The multifaceted roles of E3 ubiquitin ligases in osteoarthritis |
| title_short | The multifaceted roles of E3 ubiquitin ligases in osteoarthritis |
| title_sort | multifaceted roles of e3 ubiquitin ligases in osteoarthritis |
| topic | osteoarthritis E3 ubiquitin ligases ubiquitination mechanisms treatments |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1665313/full |
| work_keys_str_mv | AT zhengjin themultifacetedrolesofe3ubiquitinligasesinosteoarthritis AT zhenhuazhu themultifacetedrolesofe3ubiquitinligasesinosteoarthritis AT junchen themultifacetedrolesofe3ubiquitinligasesinosteoarthritis AT xiaopengjing themultifacetedrolesofe3ubiquitinligasesinosteoarthritis AT jietan themultifacetedrolesofe3ubiquitinligasesinosteoarthritis AT jizeng themultifacetedrolesofe3ubiquitinligasesinosteoarthritis AT zhengjin multifacetedrolesofe3ubiquitinligasesinosteoarthritis AT zhenhuazhu multifacetedrolesofe3ubiquitinligasesinosteoarthritis AT junchen multifacetedrolesofe3ubiquitinligasesinosteoarthritis AT xiaopengjing multifacetedrolesofe3ubiquitinligasesinosteoarthritis AT jietan multifacetedrolesofe3ubiquitinligasesinosteoarthritis AT jizeng multifacetedrolesofe3ubiquitinligasesinosteoarthritis |