Antimicrobial Efficacy of Nano-Hydroxyapatite-Coated Implants Against Peri-Implantitis-Associated Bacteria
Background: Peri-implantitis, an inflammatory condition caused by bacterial biofilms on dental implants, is a leading cause of implant failure. Nano-hydroxyapatite (nHA) coatings have been proposed to enhance the antimicrobial properties of implants and promote osseointegration. This study evaluates...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_169_25 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background:
Peri-implantitis, an inflammatory condition caused by bacterial biofilms on dental implants, is a leading cause of implant failure. Nano-hydroxyapatite (nHA) coatings have been proposed to enhance the antimicrobial properties of implants and promote osseointegration. This study evaluates the effectiveness of nHA-coated implants in inhibiting peri-implantitis-associated bacterial growth.
Materials and Methods:
Titanium dental implants were coated with nHA using the sol-gel technique. Bacterial strains commonly associated with peri-implantitis, including Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans, were cultured. The antimicrobial efficacy of nHA-coated and uncoated implants was tested using biofilm formation assays, bacterial viability assays, and scanning electron microscopy (SEM) to evaluate biofilm adhesion. Statistical analysis was conducted using ANOVA with P < 0.05 considered significant.
Results:
nHA-coated implants showed a significant reduction in bacterial adhesion and biofilm formation compared to uncoated implants (P < 0.01). The reduction rates for P. gingivalis, F. nucleatum, and A. actinomycetemcomitans were 78%, 65%, and 72%, respectively. SEM analysis revealed a smoother surface with less biofilm accumulation on nHA-coated implants. Additionally, nHA-coated surfaces exhibited enhanced antimicrobial activity without compromising biocompatibility.
Conclusion:
Nano-hydroxyapatite coatings effectively reduce bacterial colonization and biofilm formation on implant surfaces, demonstrating their potential to mitigate peri-implantitis, and improve implant longevity. Future studies should focus on clinical trials to confirm these findings in vivo. |
|---|---|
| ISSN: | 0976-4879 0975-7406 |