Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach
Bone and mineral disorders are highly prevalent in solid organ transplant recipients. These patients are at high risk for osteoporosis and fragility fractures due to several pre- and post-transplant factors, including end-stage organ disease leading to chronic malnutrition and osteomalacia, as well...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/20420188251347351 |
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| author | Soumya Kurnool Nandi Shah Preethika Ekanayake |
| author_facet | Soumya Kurnool Nandi Shah Preethika Ekanayake |
| author_sort | Soumya Kurnool |
| collection | DOAJ |
| description | Bone and mineral disorders are highly prevalent in solid organ transplant recipients. These patients are at high risk for osteoporosis and fragility fractures due to several pre- and post-transplant factors, including end-stage organ disease leading to chronic malnutrition and osteomalacia, as well as chronic immunosuppressive therapy that has direct adverse effects on bone remodeling. Low pre-transplant bone mineral density is associated with an increased risk for fragility fracture post-transplant. Furthermore, there is a precipitous loss of bone density within 6–12 months post-transplant due to a myriad of causal factors. In this review, we will elaborate on the treatment options and challenges in management of osteoporosis in solid organ recipients using vitamin D, calcium, bisphosphonates, denosumab, and osteoanabolic agents. The greatest body of evidence discusses the use of bisphosphonates, with most patients benefiting from early treatment. |
| format | Article |
| id | doaj-art-ef929d2b810e4f719fe8041401c5d8c1 |
| institution | DOAJ |
| issn | 2042-0196 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj-art-ef929d2b810e4f719fe8041401c5d8c12025-08-20T03:20:05ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01962025-06-011610.1177/20420188251347351Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approachSoumya KurnoolNandi ShahPreethika EkanayakeBone and mineral disorders are highly prevalent in solid organ transplant recipients. These patients are at high risk for osteoporosis and fragility fractures due to several pre- and post-transplant factors, including end-stage organ disease leading to chronic malnutrition and osteomalacia, as well as chronic immunosuppressive therapy that has direct adverse effects on bone remodeling. Low pre-transplant bone mineral density is associated with an increased risk for fragility fracture post-transplant. Furthermore, there is a precipitous loss of bone density within 6–12 months post-transplant due to a myriad of causal factors. In this review, we will elaborate on the treatment options and challenges in management of osteoporosis in solid organ recipients using vitamin D, calcium, bisphosphonates, denosumab, and osteoanabolic agents. The greatest body of evidence discusses the use of bisphosphonates, with most patients benefiting from early treatment.https://doi.org/10.1177/20420188251347351 |
| spellingShingle | Soumya Kurnool Nandi Shah Preethika Ekanayake Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach Therapeutic Advances in Endocrinology and Metabolism |
| title | Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach |
| title_full | Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach |
| title_fullStr | Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach |
| title_full_unstemmed | Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach |
| title_short | Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach |
| title_sort | treatment of osteoporosis in the solid organ transplant recipient an organ based approach |
| url | https://doi.org/10.1177/20420188251347351 |
| work_keys_str_mv | AT soumyakurnool treatmentofosteoporosisinthesolidorgantransplantrecipientanorganbasedapproach AT nandishah treatmentofosteoporosisinthesolidorgantransplantrecipientanorganbasedapproach AT preethikaekanayake treatmentofosteoporosisinthesolidorgantransplantrecipientanorganbasedapproach |