Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model
Background. Several studies have shown that dexmedetomidine (DXM), a selective α2-adrenoceptor agonist, also has neuroprotective effects. However, its effect on impaired peripheral nerve regeneration has not been studied. Materials and Methods. Forty-five Sprague-Dawley rats were randomly assigned t...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2017/9045608 |
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| author | Wook Jeong Hsichiang Kung Chia Chi Cheng Changwoo Lim Min Jung Jung Jaeho Lee Doo Sik Kim Yusom Shin |
| author_facet | Wook Jeong Hsichiang Kung Chia Chi Cheng Changwoo Lim Min Jung Jung Jaeho Lee Doo Sik Kim Yusom Shin |
| author_sort | Wook Jeong |
| collection | DOAJ |
| description | Background. Several studies have shown that dexmedetomidine (DXM), a selective α2-adrenoceptor agonist, also has neuroprotective effects. However, its effect on impaired peripheral nerve regeneration has not been studied. Materials and Methods. Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury + normal saline), and group 3 (sciatic nerve injury + DXM). The rats of group 3 were subdivided into the following three groups: DXM 0.5, 6, and 20 μg·kg−1 (groups 3A, 3B, and 3C, resp.). The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks. Results. There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury. However, SFI differences were statistically significant at 6 weeks postinjury in group 3. The gross findings with H&E staining showed that the number of axons was higher in group 3 than in group 2. There was no histological difference according to the DXM concentration. Conclusion. The coincidental functional and histological assessment results of this study suggest that DXM for 6 weeks positively affects damaged peripheral nerves. |
| format | Article |
| id | doaj-art-ef9248389f8c42d6851a397257648419 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-ef9248389f8c42d6851a3972576484192025-02-03T01:22:08ZengWileyPain Research and Management1203-67651918-15232017-01-01201710.1155/2017/90456089045608Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury ModelWook Jeong0Hsichiang Kung1Chia Chi Cheng2Changwoo Lim3Min Jung Jung4Jaeho Lee5Doo Sik Kim6Yusom Shin7Department of Anesthesiology and Pain Medicine, Suryeoan Clinic, Busan, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Republic of KoreaDepartment of Pathology, Kosin University College of Medicine, Busan, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Ulsan University College of Medicine, Ulsan, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Republic of KoreaBackground. Several studies have shown that dexmedetomidine (DXM), a selective α2-adrenoceptor agonist, also has neuroprotective effects. However, its effect on impaired peripheral nerve regeneration has not been studied. Materials and Methods. Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury + normal saline), and group 3 (sciatic nerve injury + DXM). The rats of group 3 were subdivided into the following three groups: DXM 0.5, 6, and 20 μg·kg−1 (groups 3A, 3B, and 3C, resp.). The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks. Results. There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury. However, SFI differences were statistically significant at 6 weeks postinjury in group 3. The gross findings with H&E staining showed that the number of axons was higher in group 3 than in group 2. There was no histological difference according to the DXM concentration. Conclusion. The coincidental functional and histological assessment results of this study suggest that DXM for 6 weeks positively affects damaged peripheral nerves.http://dx.doi.org/10.1155/2017/9045608 |
| spellingShingle | Wook Jeong Hsichiang Kung Chia Chi Cheng Changwoo Lim Min Jung Jung Jaeho Lee Doo Sik Kim Yusom Shin Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model Pain Research and Management |
| title | Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model |
| title_full | Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model |
| title_fullStr | Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model |
| title_full_unstemmed | Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model |
| title_short | Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model |
| title_sort | dexmedetomidine to help nerve regeneration in a rat sciatic nerve injury model |
| url | http://dx.doi.org/10.1155/2017/9045608 |
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