Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis
Abstract Sepsis is a life-threatening condition characterized by overactivated inflammation and a dysregulated immune response caused by infection. The predominant mechanism underlying the vulnerability and severity of sepsis has not been fully elucidated. Liquid‒liquid phase separation (LLPS) is a...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02599-2 |
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| _version_ | 1849333731431546880 |
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| author | Huiyi Chen Shunyi Huang Longcheng Quan Caiyuan Yu Yang Zhu Xiaocong Sun Yuanli Zhang Liehua Deng Feng Chen |
| author_facet | Huiyi Chen Shunyi Huang Longcheng Quan Caiyuan Yu Yang Zhu Xiaocong Sun Yuanli Zhang Liehua Deng Feng Chen |
| author_sort | Huiyi Chen |
| collection | DOAJ |
| description | Abstract Sepsis is a life-threatening condition characterized by overactivated inflammation and a dysregulated immune response caused by infection. The predominant mechanism underlying the vulnerability and severity of sepsis has not been fully elucidated. Liquid‒liquid phase separation (LLPS) is a recently discovered, powerful mechanism that drives the formation of membraneless organelles and their biological functions. In particular, emerging evidence indicates that multiple core proteins involved in immune responses, inflammatory signalling, and programmed cell death are organized as protein condensates through LLPS. Here, we present an up-to-date review of the hypothesis that LLPS may underlie the fundamental mechanisms of sepsis, with a focus on the immune system response, changes in inflammatory signalling, and programmed cell death, with the goal of advancing our understanding of the pathological mechanisms of sepsis. |
| format | Article |
| id | doaj-art-ef8ffe5bd3c24c98bb612f7e33731474 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-ef8ffe5bd3c24c98bb612f7e337314742025-08-20T03:45:45ZengNature Publishing GroupCell Death Discovery2058-77162025-07-0111111110.1038/s41420-025-02599-2Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsisHuiyi Chen0Shunyi Huang1Longcheng Quan2Caiyuan Yu3Yang Zhu4Xiaocong Sun5Yuanli Zhang6Liehua Deng7Feng Chen8Department of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Gerontology, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityDepartment of Critical Care Medicine, The Affiliated Hospital of Guangdong Medical UniversityAbstract Sepsis is a life-threatening condition characterized by overactivated inflammation and a dysregulated immune response caused by infection. The predominant mechanism underlying the vulnerability and severity of sepsis has not been fully elucidated. Liquid‒liquid phase separation (LLPS) is a recently discovered, powerful mechanism that drives the formation of membraneless organelles and their biological functions. In particular, emerging evidence indicates that multiple core proteins involved in immune responses, inflammatory signalling, and programmed cell death are organized as protein condensates through LLPS. Here, we present an up-to-date review of the hypothesis that LLPS may underlie the fundamental mechanisms of sepsis, with a focus on the immune system response, changes in inflammatory signalling, and programmed cell death, with the goal of advancing our understanding of the pathological mechanisms of sepsis.https://doi.org/10.1038/s41420-025-02599-2 |
| spellingShingle | Huiyi Chen Shunyi Huang Longcheng Quan Caiyuan Yu Yang Zhu Xiaocong Sun Yuanli Zhang Liehua Deng Feng Chen Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis Cell Death Discovery |
| title | Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis |
| title_full | Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis |
| title_fullStr | Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis |
| title_full_unstemmed | Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis |
| title_short | Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis |
| title_sort | liquid liquid phase separation a potentially fundamental mechanism of sepsis |
| url | https://doi.org/10.1038/s41420-025-02599-2 |
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