Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida
The <i>Candida</i> species cell wall plays a pivotal role as a structural and functional barrier against external aggressors and as an intermediary in host–pathogen interactions. <i>Candida</i> species exhibit unique adaptations in their cell wall composition, with varying pr...
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MDPI AG
2025-04-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/11/4/271 |
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| author | Iván A. Banda-Flores David Torres-Tirado Héctor M. Mora-Montes Gabriela Pérez-Flores Luis A. Pérez-García |
| author_facet | Iván A. Banda-Flores David Torres-Tirado Héctor M. Mora-Montes Gabriela Pérez-Flores Luis A. Pérez-García |
| author_sort | Iván A. Banda-Flores |
| collection | DOAJ |
| description | The <i>Candida</i> species cell wall plays a pivotal role as a structural and functional barrier against external aggressors and as an intermediary in host–pathogen interactions. <i>Candida</i> species exhibit unique adaptations in their cell wall composition, with varying proportions of chitin, mannans, and β-glucans influenced by the environmental conditions and the morphological states. These components not only maintain cellular viability under osmotic, thermal, and chemical stress, but also serve as the key targets for novel antifungal strategies. MAPK signaling pathways, like the cell wall integrity pathway and the high-osmolarity glycerol pathway, play a crucial role in responding to cell wall stressors. Due to the rise of antifungal resistance and its clinical challenges, there is a need to identify new antifungal targets. This review discusses the recent advances in understanding the mechanisms underlying cell wall integrity, their impact on antifungal resistance and virulence, and their potential as therapeutic targets of <i>C. albicans</i>, <i>N. glabratus</i>, and <i>C. auris</i>. |
| format | Article |
| id | doaj-art-ef8fb349fece4a04887ffcb8491f9bc7 |
| institution | OA Journals |
| issn | 2309-608X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-ef8fb349fece4a04887ffcb8491f9bc72025-08-20T02:28:37ZengMDPI AGJournal of Fungi2309-608X2025-04-0111427110.3390/jof11040271Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant CandidaIván A. Banda-Flores0David Torres-Tirado1Héctor M. Mora-Montes2Gabriela Pérez-Flores3Luis A. Pérez-García4Facultad de Estudios Profesionales Zona Huasteca, Universidad Autónoma de San Luis Potosí, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosi, MexicoFacultad de Estudios Profesionales Zona Huasteca, Universidad Autónoma de San Luis Potosí, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosi, MexicoDepartamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Col. Noria Alta, Guanajuato 36050, Guanajuato, MexicoFacultad de Estudios Profesionales Zona Huasteca, Universidad Autónoma de San Luis Potosí, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosi, MexicoFacultad de Estudios Profesionales Zona Huasteca, Universidad Autónoma de San Luis Potosí, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosi, MexicoThe <i>Candida</i> species cell wall plays a pivotal role as a structural and functional barrier against external aggressors and as an intermediary in host–pathogen interactions. <i>Candida</i> species exhibit unique adaptations in their cell wall composition, with varying proportions of chitin, mannans, and β-glucans influenced by the environmental conditions and the morphological states. These components not only maintain cellular viability under osmotic, thermal, and chemical stress, but also serve as the key targets for novel antifungal strategies. MAPK signaling pathways, like the cell wall integrity pathway and the high-osmolarity glycerol pathway, play a crucial role in responding to cell wall stressors. Due to the rise of antifungal resistance and its clinical challenges, there is a need to identify new antifungal targets. This review discusses the recent advances in understanding the mechanisms underlying cell wall integrity, their impact on antifungal resistance and virulence, and their potential as therapeutic targets of <i>C. albicans</i>, <i>N. glabratus</i>, and <i>C. auris</i>.https://www.mdpi.com/2309-608X/11/4/271<i>Candida</i>cell walltherapeutic targets<i>Candida albicans</i><i>Nakaseomyces glabratus</i><i>Candida auris</i> |
| spellingShingle | Iván A. Banda-Flores David Torres-Tirado Héctor M. Mora-Montes Gabriela Pérez-Flores Luis A. Pérez-García Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida Journal of Fungi <i>Candida</i> cell wall therapeutic targets <i>Candida albicans</i> <i>Nakaseomyces glabratus</i> <i>Candida auris</i> |
| title | Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida |
| title_full | Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida |
| title_fullStr | Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida |
| title_full_unstemmed | Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida |
| title_short | Resilience in Resistance: The Role of Cell Wall Integrity in Multidrug-Resistant Candida |
| title_sort | resilience in resistance the role of cell wall integrity in multidrug resistant candida |
| topic | <i>Candida</i> cell wall therapeutic targets <i>Candida albicans</i> <i>Nakaseomyces glabratus</i> <i>Candida auris</i> |
| url | https://www.mdpi.com/2309-608X/11/4/271 |
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