Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis
This study aimed to identify biomarkers that could enhance the accuracy of diagnosing reversible and irreversible pulpitis. This systematic review was conducted in adherence to the guidelines outlined in PRISMA. A total of twelve studies were included for analysis. A meta-analysis of nine studies sh...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1806_24 |
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| _version_ | 1849734380984991744 |
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| author | Aparna Rai Saloni Jain Minhaj A. Khan Mohd Abbas Ansari Astha Agrawal Aisha Begum |
| author_facet | Aparna Rai Saloni Jain Minhaj A. Khan Mohd Abbas Ansari Astha Agrawal Aisha Begum |
| author_sort | Aparna Rai |
| collection | DOAJ |
| description | This study aimed to identify biomarkers that could enhance the accuracy of diagnosing reversible and irreversible pulpitis. This systematic review was conducted in adherence to the guidelines outlined in PRISMA. A total of twelve studies were included for analysis. A meta-analysis of nine studies showed an overall effect of 9.91 with a P value of less than 0.00001. Eight out of the nine studies favored the control group. The studies exhibited substantial variation, with an I-square value of 99%, indicating significant heterogeneity (P < 0.00001). According to this systemic review, the expression of IL-8, TNF-a, MMP-9, and RAGE gene and protein was increased in pulp samples from teeth clinically diagnosed with irreversible symptomatic pulpitis. |
| format | Article |
| id | doaj-art-ef8fa02a4e454724a6127451e73eb081 |
| institution | DOAJ |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-ef8fa02a4e454724a6127451e73eb0812025-08-20T03:07:49ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S188S19010.4103/jpbs.jpbs_1806_24Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-AnalysisAparna RaiSaloni JainMinhaj A. KhanMohd Abbas AnsariAstha AgrawalAisha BegumThis study aimed to identify biomarkers that could enhance the accuracy of diagnosing reversible and irreversible pulpitis. This systematic review was conducted in adherence to the guidelines outlined in PRISMA. A total of twelve studies were included for analysis. A meta-analysis of nine studies showed an overall effect of 9.91 with a P value of less than 0.00001. Eight out of the nine studies favored the control group. The studies exhibited substantial variation, with an I-square value of 99%, indicating significant heterogeneity (P < 0.00001). According to this systemic review, the expression of IL-8, TNF-a, MMP-9, and RAGE gene and protein was increased in pulp samples from teeth clinically diagnosed with irreversible symptomatic pulpitis.https://journals.lww.com/10.4103/jpbs.jpbs_1806_24markerspulppulpitis |
| spellingShingle | Aparna Rai Saloni Jain Minhaj A. Khan Mohd Abbas Ansari Astha Agrawal Aisha Begum Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis Journal of Pharmacy and Bioallied Sciences markers pulp pulpitis |
| title | Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis |
| title_full | Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis |
| title_fullStr | Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis |
| title_short | Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis |
| title_sort | biomarkers of reversible and irreversible pulpitis systematic review and meta analysis |
| topic | markers pulp pulpitis |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1806_24 |
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