Clonal hematopoiesis and acute myeloid leukemia
During aging phenotypic changes in the hematopoietic system occur, and possible reason of these changes can be accumulation of gene mutations in hematopoietic stem cells or early blood progenitors. Although these mutations are mostly neutral, some may give hematopoietic stem cells and progenitor cel...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2023-09-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/841 |
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| author | A. I. Kashlakova B. V. Biderman E. N. Parovichnikova |
| author_facet | A. I. Kashlakova B. V. Biderman E. N. Parovichnikova |
| author_sort | A. I. Kashlakova |
| collection | DOAJ |
| description | During aging phenotypic changes in the hematopoietic system occur, and possible reason of these changes can be accumulation of gene mutations in hematopoietic stem cells or early blood progenitors. Although these mutations are mostly neutral, some may give hematopoietic stem cells and progenitor cells a proliferative advantage. In this case clonal hematopoiesis will arise, which is characterized by the formation of a genetically distinct subpopulation of blood cells. Clonal hematopoiesis may become a basis for the development of hematologic malignancies, such as acute myeloid leukemia. Clonal hematopoiesis associated genes which are most commonly mutated in acute myeloid leukemia patients are DNMT3A, TET2 and ASXL1. The prognostic significance of these gene mutations currently remains a subject of study. |
| format | Article |
| id | doaj-art-ef8eada3c6c44d948a733ed1ae7d2d22 |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-ef8eada3c6c44d948a733ed1ae7d2d222025-08-20T03:35:33ZrusABV-pressОнкогематология1818-83462413-40232023-09-011839210110.17650/1818-8346-2023-18-3-92-101702Clonal hematopoiesis and acute myeloid leukemiaA. I. Kashlakova0B. V. Biderman1E. N. Parovichnikova2National Medical Research Center for Hematology, Ministry of Health of RussiaNational Medical Research Center for Hematology, Ministry of Health of RussiaNational Medical Research Center for Hematology, Ministry of Health of RussiaDuring aging phenotypic changes in the hematopoietic system occur, and possible reason of these changes can be accumulation of gene mutations in hematopoietic stem cells or early blood progenitors. Although these mutations are mostly neutral, some may give hematopoietic stem cells and progenitor cells a proliferative advantage. In this case clonal hematopoiesis will arise, which is characterized by the formation of a genetically distinct subpopulation of blood cells. Clonal hematopoiesis may become a basis for the development of hematologic malignancies, such as acute myeloid leukemia. Clonal hematopoiesis associated genes which are most commonly mutated in acute myeloid leukemia patients are DNMT3A, TET2 and ASXL1. The prognostic significance of these gene mutations currently remains a subject of study.https://oncohematology.abvpress.ru/ongm/article/view/841acute myeloid leukemiaclonal hematopoiesisgene mutation |
| spellingShingle | A. I. Kashlakova B. V. Biderman E. N. Parovichnikova Clonal hematopoiesis and acute myeloid leukemia Онкогематология acute myeloid leukemia clonal hematopoiesis gene mutation |
| title | Clonal hematopoiesis and acute myeloid leukemia |
| title_full | Clonal hematopoiesis and acute myeloid leukemia |
| title_fullStr | Clonal hematopoiesis and acute myeloid leukemia |
| title_full_unstemmed | Clonal hematopoiesis and acute myeloid leukemia |
| title_short | Clonal hematopoiesis and acute myeloid leukemia |
| title_sort | clonal hematopoiesis and acute myeloid leukemia |
| topic | acute myeloid leukemia clonal hematopoiesis gene mutation |
| url | https://oncohematology.abvpress.ru/ongm/article/view/841 |
| work_keys_str_mv | AT aikashlakova clonalhematopoiesisandacutemyeloidleukemia AT bvbiderman clonalhematopoiesisandacutemyeloidleukemia AT enparovichnikova clonalhematopoiesisandacutemyeloidleukemia |