Hydrogen sulfide alleviates high-salt-stimulated myocardial fibrosis through inhibiting hypoxia-inducible factor-1α

Hydrogen sulfide alleviates high-salt-stimulated myocardial fibrosis through inhibiting hypoxia-inducible factor-1α

BackgroundEndogenous hydrogen sulfide (H2S) and its key generating enzyme, cystathionine β-synthase (CBS), prevent vascular remodeling and damage to target organs during the advancement of hypertension induced by a high-salt diet.ObjectiveThe contribution of the H2S/CBS pathway to high-salt–induced...

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Bibliographic Details
Main Authors: Qian Peng, Pan Huang, Boyang Lv, Chaoshu Tang, Hongfang Jin, Yaqian Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
hydrogen sulfide
high-salt diet
HIF-1α
myocardial fibrosis
cardiac fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1502269/full
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