Correlation between carotid artery ultrasound parameters and lacunar infarction
Abstract Objective This study aims to investigate the correlation between the imaging characteristics of lacunar infarction (LI) and carotid artery ultrasound parameters within a community-based population. Methods A total of 630 participants were included to undergo brain MRI and carotid ultrasound...
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BMC
2025-08-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01859-y |
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| author | Peipei Yang Ying Hui Shuohua Chen Xinyu Zhao Wei Huang Xiaoshuai Li Shouling Wu Yuntao Wu Ling Yang Jing Chen Zhenchang Wang Xian-Quan Shi |
| author_facet | Peipei Yang Ying Hui Shuohua Chen Xinyu Zhao Wei Huang Xiaoshuai Li Shouling Wu Yuntao Wu Ling Yang Jing Chen Zhenchang Wang Xian-Quan Shi |
| author_sort | Peipei Yang |
| collection | DOAJ |
| description | Abstract Objective This study aims to investigate the correlation between the imaging characteristics of lacunar infarction (LI) and carotid artery ultrasound parameters within a community-based population. Methods A total of 630 participants were included to undergo brain MRI and carotid ultrasound examinations, with their demographic and clinical characteristics systematically documented. Ultrasound imaging was used to quantify the structural, hemodynamic, and stiffness parameters of the common carotid artery (CCA) and internal carotid artery (ICA). Additionally, the associations between these parameters and the imaging features of LI were comprehensively analyzed. Result The mean age of the participants was about 55.21 ± 10.98 years, and the prevalence of LI was 13.02% (82/630). As shown by correlation analysis, all carotid artery ultrasound parameters exhibited significant correlations with LI except for ICA-PSV. Internal diameter of CCA and ICA, plaque in CCA and ICA, resistance index (RI) of CCA and ICA, pulsatility indexes (PI) of CCA and ICA, systolic/diastolic(S/D) of CCA and ICA, and carotid-femoral pulse wave velocity (cf-PWV) were positively associated with LI; peak systolic velocities (PSV) of CCA, end-diastolic velocities (EDV) of CCA and ICA, average velocity (AVG) of CCA and ICA were negatively associated with LI. Multivariate regression analysis showed that CCA-internal diameter (95%CI, 1.04–1.93; p = 0.025), CCA-plaque (bilateral) (95%CI, 1.06–4.37; p = 0.034), and cf-PWV (95%CI, 1.01–1.15; p = 0.017) were independent factors of presence of LI. Conclusion Arterial plaque burden and stiffness-related parameters assessed through carotid artery ultrasound, such as CCA-internal diameter, CCA-plaque, and cf-PWV, show predictive value for the risk of LI. |
| format | Article |
| id | doaj-art-ef89781f76dc4b959b6ae4080e19f8d4 |
| institution | Kabale University |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj-art-ef89781f76dc4b959b6ae4080e19f8d42025-08-20T04:02:44ZengBMCBMC Medical Imaging1471-23422025-08-012511910.1186/s12880-025-01859-yCorrelation between carotid artery ultrasound parameters and lacunar infarctionPeipei Yang0Ying Hui1Shuohua Chen2Xinyu Zhao3Wei Huang4Xiaoshuai Li5Shouling Wu6Yuntao Wu7Ling Yang8Jing Chen9Zhenchang Wang10Xian-Quan Shi11Department of Ultrasound, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Medical Imaging, KaiLuan General HospitalDepartment of Cardiology, KaiLuan General HospitalClinical Epidemiology and EBM Unit, Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Ultrasound, KaiLuan General HospitalDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Cardiology, KaiLuan General HospitalDepartment of Cardiology, KaiLuan General HospitalDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Medical Imaging, KaiLuan General HospitalDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Ultrasound, Beijing Friendship Hospital, Capital Medical UniversityAbstract Objective This study aims to investigate the correlation between the imaging characteristics of lacunar infarction (LI) and carotid artery ultrasound parameters within a community-based population. Methods A total of 630 participants were included to undergo brain MRI and carotid ultrasound examinations, with their demographic and clinical characteristics systematically documented. Ultrasound imaging was used to quantify the structural, hemodynamic, and stiffness parameters of the common carotid artery (CCA) and internal carotid artery (ICA). Additionally, the associations between these parameters and the imaging features of LI were comprehensively analyzed. Result The mean age of the participants was about 55.21 ± 10.98 years, and the prevalence of LI was 13.02% (82/630). As shown by correlation analysis, all carotid artery ultrasound parameters exhibited significant correlations with LI except for ICA-PSV. Internal diameter of CCA and ICA, plaque in CCA and ICA, resistance index (RI) of CCA and ICA, pulsatility indexes (PI) of CCA and ICA, systolic/diastolic(S/D) of CCA and ICA, and carotid-femoral pulse wave velocity (cf-PWV) were positively associated with LI; peak systolic velocities (PSV) of CCA, end-diastolic velocities (EDV) of CCA and ICA, average velocity (AVG) of CCA and ICA were negatively associated with LI. Multivariate regression analysis showed that CCA-internal diameter (95%CI, 1.04–1.93; p = 0.025), CCA-plaque (bilateral) (95%CI, 1.06–4.37; p = 0.034), and cf-PWV (95%CI, 1.01–1.15; p = 0.017) were independent factors of presence of LI. Conclusion Arterial plaque burden and stiffness-related parameters assessed through carotid artery ultrasound, such as CCA-internal diameter, CCA-plaque, and cf-PWV, show predictive value for the risk of LI.https://doi.org/10.1186/s12880-025-01859-yLacunar infarction (LI)Multiparametric carotid ultrasoundBrain MRICarotid-femoral pulse wave velocity (cf-PWV) |
| spellingShingle | Peipei Yang Ying Hui Shuohua Chen Xinyu Zhao Wei Huang Xiaoshuai Li Shouling Wu Yuntao Wu Ling Yang Jing Chen Zhenchang Wang Xian-Quan Shi Correlation between carotid artery ultrasound parameters and lacunar infarction BMC Medical Imaging Lacunar infarction (LI) Multiparametric carotid ultrasound Brain MRI Carotid-femoral pulse wave velocity (cf-PWV) |
| title | Correlation between carotid artery ultrasound parameters and lacunar infarction |
| title_full | Correlation between carotid artery ultrasound parameters and lacunar infarction |
| title_fullStr | Correlation between carotid artery ultrasound parameters and lacunar infarction |
| title_full_unstemmed | Correlation between carotid artery ultrasound parameters and lacunar infarction |
| title_short | Correlation between carotid artery ultrasound parameters and lacunar infarction |
| title_sort | correlation between carotid artery ultrasound parameters and lacunar infarction |
| topic | Lacunar infarction (LI) Multiparametric carotid ultrasound Brain MRI Carotid-femoral pulse wave velocity (cf-PWV) |
| url | https://doi.org/10.1186/s12880-025-01859-y |
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