Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats

Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats

Skeletal muscle changes occur in heart failure (HF). Despite the cardioprotective effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors in HF, their impact on skeletal muscle remains poorly understood. We investigated the effects of the SGLT2 inhibitor empagliflozin (EMPA) on cardiac remodel...

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Main Authors: Lidiane Moreira Souza, Felipe Cesar Damatto, Bruna Brasil Brandão, Eder Anderson Rodrigues, Anna Clara Consorti Santos, Rafael Campos França Silva, Mariana Gatto, Luana Urbano Pagan, Paula Felippe Martinez, Gilson Masahiro Murata, Leonardo Antonio Mamede Zornoff, Paula Schmidt Azevedo Gaiolla, Inês Falcão-Pires, Katashi Okoshi, Marina Politi Okoshi
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
myocardial infarction
soleus muscle
oxidative stress
energy metabolism
mitochondrial function
IGF-1 pathway
Online Access:https://www.mdpi.com/2076-3921/14/6/647
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