FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to treat malignancy and some solid tumors which may be accompanied by life-threatening immune and infectious complications refractory to standard immunosuppressive and antibacterial therapy. According to literature...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2019-07-01
|
| Series: | Вестник анестезиологии и реаниматологии |
| Subjects: | |
| Online Access: | https://www.vair-journal.com/jour/article/view/338 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849344027015512064 |
|---|---|
| author | O. V. GOLOSHCHAPOV D. V. CHURAKINA M. А. KUCHER R. V. KLEMENTEVA S. V. SIDORENKO V. V. GOSTEV V. Е. KAREV М. А. SUVOROVA I. V. SHLYK А. B. CHUKHLOVIN L. S. ZUBAROVSKAYA B. V. AFANASYEV |
| author_facet | O. V. GOLOSHCHAPOV D. V. CHURAKINA M. А. KUCHER R. V. KLEMENTEVA S. V. SIDORENKO V. V. GOSTEV V. Е. KAREV М. А. SUVOROVA I. V. SHLYK А. B. CHUKHLOVIN L. S. ZUBAROVSKAYA B. V. AFANASYEV |
| author_sort | O. V. GOLOSHCHAPOV |
| collection | DOAJ |
| description | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to treat malignancy and some solid tumors which may be accompanied by life-threatening immune and infectious complications refractory to standard immunosuppressive and antibacterial therapy. According to literature data, fecal microbiota transplantation (FMT) may be applied to restore functional activity of microbiota and to overcome antibiotic resistance. Two clinical cases of FMT in critical ill patients who had developed acute graft-versus-host disease (aGvHD) of intestine after allo-HSCT are presented in the article. The aim of the study was to assess FMT efficiency and safety in immunocompromised critically ill patients. Results. Following FMT, a complete regress of aGvHD signs as well as reduction of systemic infectious process were registered, due to probable modulation of the immune response. In one patient, elimination from respiratory ways of carbapenemase-producing Klebsiella pneumoniae positive for NDM- and OXA-48- producing was noted, like as elimination of Pseudomonas aeruginosa synthesizing KRS-type carbapenemase. Conclusions. FMT may be considered an alternative approach to intestinal aGvHD treatment in critically ill patients after allo-HSCT. |
| format | Article |
| id | doaj-art-ef7e2e0d835b4d2784959be54c09cf47 |
| institution | Kabale University |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-ef7e2e0d835b4d2784959be54c09cf472025-08-20T03:42:47ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532019-07-01163637310.21292/2078-5658-2019-16-3-63-73317FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICEO. V. GOLOSHCHAPOV0D. V. CHURAKINA1M. А. KUCHER2R. V. KLEMENTEVA3S. V. SIDORENKO4V. V. GOSTEV5V. Е. KAREV6М. А. SUVOROVA7I. V. SHLYK8А. B. CHUKHLOVIN9L. S. ZUBAROVSKAYA10B. V. AFANASYEV11Raisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityPediatric Research and Clinical Center for Infectious DiseasesRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityPediatric Research and Clinical Center for Infectious DiseasesThe Explana Research LaboratoryRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityRaisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical UniversityAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to treat malignancy and some solid tumors which may be accompanied by life-threatening immune and infectious complications refractory to standard immunosuppressive and antibacterial therapy. According to literature data, fecal microbiota transplantation (FMT) may be applied to restore functional activity of microbiota and to overcome antibiotic resistance. Two clinical cases of FMT in critical ill patients who had developed acute graft-versus-host disease (aGvHD) of intestine after allo-HSCT are presented in the article. The aim of the study was to assess FMT efficiency and safety in immunocompromised critically ill patients. Results. Following FMT, a complete regress of aGvHD signs as well as reduction of systemic infectious process were registered, due to probable modulation of the immune response. In one patient, elimination from respiratory ways of carbapenemase-producing Klebsiella pneumoniae positive for NDM- and OXA-48- producing was noted, like as elimination of Pseudomonas aeruginosa synthesizing KRS-type carbapenemase. Conclusions. FMT may be considered an alternative approach to intestinal aGvHD treatment in critically ill patients after allo-HSCT.https://www.vair-journal.com/jour/article/view/338fecal microbiota transplantationgraft versus host diseasesepsis treatmentdecolonizationcarbapenemasesmetalloproteinasendmoxa-48крс factorsklebsiella pneumoniaepseudomonas aeruginosa |
| spellingShingle | O. V. GOLOSHCHAPOV D. V. CHURAKINA M. А. KUCHER R. V. KLEMENTEVA S. V. SIDORENKO V. V. GOSTEV V. Е. KAREV М. А. SUVOROVA I. V. SHLYK А. B. CHUKHLOVIN L. S. ZUBAROVSKAYA B. V. AFANASYEV FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE Вестник анестезиологии и реаниматологии fecal microbiota transplantation graft versus host disease sepsis treatment decolonization carbapenemases metalloproteinase ndm oxa-48 крс factors klebsiella pneumoniae pseudomonas aeruginosa |
| title | FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE |
| title_full | FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE |
| title_fullStr | FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE |
| title_full_unstemmed | FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE |
| title_short | FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE |
| title_sort | fecal microbiota transplantation in critical condition patients in hematological practice |
| topic | fecal microbiota transplantation graft versus host disease sepsis treatment decolonization carbapenemases metalloproteinase ndm oxa-48 крс factors klebsiella pneumoniae pseudomonas aeruginosa |
| url | https://www.vair-journal.com/jour/article/view/338 |
| work_keys_str_mv | AT ovgoloshchapov fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT dvchurakina fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT makucher fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT rvklementeva fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT svsidorenko fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT vvgostev fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT vekarev fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT masuvorova fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT ivshlyk fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT abchukhlovin fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT lszubarovskaya fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice AT bvafanasyev fecalmicrobiotatransplantationincriticalconditionpatientsinhematologicalpractice |