Deciphering Asthma Biomarkers with Protein Profiling Technology
Asthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/630637 |
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| _version_ | 1849690690873720832 |
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| author | Zhizhou Kuang Jarad J. Wilson Shuhong Luo Si-Wei Zhu Ruo-Pan Huang |
| author_facet | Zhizhou Kuang Jarad J. Wilson Shuhong Luo Si-Wei Zhu Ruo-Pan Huang |
| author_sort | Zhizhou Kuang |
| collection | DOAJ |
| description | Asthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic given that the disease consists of many variants, each with its own etiologic and pathophysiologic factors, including different cellular responses and inflammatory phenotypes. These facets make the rapid and accurate diagnosis (not to mention treatments) of asthma extremely difficult. Protein biomarkers can serve as powerful detection tools in both clinical and basic research applications. Recent endeavors from biomedical researchers have developed technical platforms, such as cytokine antibody arrays, that have been employed and used to further the global analysis of asthma biomarker studies. In this review, we discuss potential asthma biomarkers involved in the pathophysiologic process and eventual pathogenesis of asthma, how these biomarkers are being utilized, and how further testing methods might help improve the diagnosis and treatment strain that current asthma patients suffer. |
| format | Article |
| id | doaj-art-ef7c8adb821e4ed193485bbf8f719931 |
| institution | DOAJ |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-ef7c8adb821e4ed193485bbf8f7199312025-08-20T03:21:15ZengWileyInternational Journal of Inflammation2090-80402042-00992015-01-01201510.1155/2015/630637630637Deciphering Asthma Biomarkers with Protein Profiling TechnologyZhizhou Kuang0Jarad J. Wilson1Shuhong Luo2Si-Wei Zhu3Ruo-Pan Huang4RayBiotech, Inc., Guangzhou 510600, ChinaRayBiotech, Inc., 3607 Parkway Lane, Norcross, GA 30092, USARayBiotech, Inc., Guangzhou 510600, ChinaRayBiotech, Inc., Guangzhou 510600, ChinaRayBiotech, Inc., Guangzhou 510600, ChinaAsthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic given that the disease consists of many variants, each with its own etiologic and pathophysiologic factors, including different cellular responses and inflammatory phenotypes. These facets make the rapid and accurate diagnosis (not to mention treatments) of asthma extremely difficult. Protein biomarkers can serve as powerful detection tools in both clinical and basic research applications. Recent endeavors from biomedical researchers have developed technical platforms, such as cytokine antibody arrays, that have been employed and used to further the global analysis of asthma biomarker studies. In this review, we discuss potential asthma biomarkers involved in the pathophysiologic process and eventual pathogenesis of asthma, how these biomarkers are being utilized, and how further testing methods might help improve the diagnosis and treatment strain that current asthma patients suffer.http://dx.doi.org/10.1155/2015/630637 |
| spellingShingle | Zhizhou Kuang Jarad J. Wilson Shuhong Luo Si-Wei Zhu Ruo-Pan Huang Deciphering Asthma Biomarkers with Protein Profiling Technology International Journal of Inflammation |
| title | Deciphering Asthma Biomarkers with Protein Profiling Technology |
| title_full | Deciphering Asthma Biomarkers with Protein Profiling Technology |
| title_fullStr | Deciphering Asthma Biomarkers with Protein Profiling Technology |
| title_full_unstemmed | Deciphering Asthma Biomarkers with Protein Profiling Technology |
| title_short | Deciphering Asthma Biomarkers with Protein Profiling Technology |
| title_sort | deciphering asthma biomarkers with protein profiling technology |
| url | http://dx.doi.org/10.1155/2015/630637 |
| work_keys_str_mv | AT zhizhoukuang decipheringasthmabiomarkerswithproteinprofilingtechnology AT jaradjwilson decipheringasthmabiomarkerswithproteinprofilingtechnology AT shuhongluo decipheringasthmabiomarkerswithproteinprofilingtechnology AT siweizhu decipheringasthmabiomarkerswithproteinprofilingtechnology AT ruopanhuang decipheringasthmabiomarkerswithproteinprofilingtechnology |