C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients
Objective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR...
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| Language: | Russian |
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IMA-PRESS LLC
2022-05-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/1270 |
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| author | Elsabagh Abdou Amira Abd-Elwahab Selim Heba Mohamed Mohyeldin Amany Ahmed Hany Marwa |
| author_facet | Elsabagh Abdou Amira Abd-Elwahab Selim Heba Mohamed Mohyeldin Amany Ahmed Hany Marwa |
| author_sort | Elsabagh Abdou Amira |
| collection | DOAJ |
| description | Objective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR/CAR and DAS28 in RA.Patients and methods. A case control study including 30 RA patients and 30 healthy controls was performed. Fibrinogen, albumin, CRP and erythrocyte sedimentation rate (ESR) were measured. We calculated CAR and AFR in each group and compared them. Correlations of AFR, and CAR with disease activity were examined. Receiver operation characteristic (ROC) curves of AFR and CAR were also used to detect cutoffs for disease activity assessment.Results and discussion. CAR was higher while AFR was lower in RA patients than in control group. ROC curve analyses showed that CAR can be used to detect disease activity of RA at cut off 2.66 with sensitivity 81.3% and specificity 64.3% with an area under the curve (AUC) 0.78. So, CAR was a fair parameter to discriminate disease activity among RA patients. AFR has AUC 0.62, sensitivity 87.5% and specificity 42.9% at cutoff value 5.96. So, in our group AFR was a poor indicator to discriminate disease activity among RA patients.Conclusion. AFR and CAR have been recently proposed as inflammatory markers for assessment of disease activity in RA. AFR and CAR are simple, and inexpensive biomarkers, they also can be rapidly evaluated. CAR was found to be a fair parameter to depict disease activity in RA patients. AFR poorly depicted RA activity. |
| format | Article |
| id | doaj-art-ef79493f809b404ea906a008ac578b87 |
| institution | Kabale University |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-ef79493f809b404ea906a008ac578b872025-08-20T03:44:21ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2022-05-01162212510.14412/1996-7012-2022-2-21-252460C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis PatientsElsabagh Abdou Amira0Abd-Elwahab Selim Heba1Mohamed Mohyeldin Amany2Ahmed Hany Marwa3Rheumatology, Rehabilitation and Physical Medicine Department, Al Qanayat hospitalRheumatology and Rehabilitation Department Zagazig UniversityClinical & Chemical Pathology Department, Faculty of Medicine, Zagazig UniversityRheumatology and Rehabilitation Department Zagazig UniversityObjective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR/CAR and DAS28 in RA.Patients and methods. A case control study including 30 RA patients and 30 healthy controls was performed. Fibrinogen, albumin, CRP and erythrocyte sedimentation rate (ESR) were measured. We calculated CAR and AFR in each group and compared them. Correlations of AFR, and CAR with disease activity were examined. Receiver operation characteristic (ROC) curves of AFR and CAR were also used to detect cutoffs for disease activity assessment.Results and discussion. CAR was higher while AFR was lower in RA patients than in control group. ROC curve analyses showed that CAR can be used to detect disease activity of RA at cut off 2.66 with sensitivity 81.3% and specificity 64.3% with an area under the curve (AUC) 0.78. So, CAR was a fair parameter to discriminate disease activity among RA patients. AFR has AUC 0.62, sensitivity 87.5% and specificity 42.9% at cutoff value 5.96. So, in our group AFR was a poor indicator to discriminate disease activity among RA patients.Conclusion. AFR and CAR have been recently proposed as inflammatory markers for assessment of disease activity in RA. AFR and CAR are simple, and inexpensive biomarkers, they also can be rapidly evaluated. CAR was found to be a fair parameter to depict disease activity in RA patients. AFR poorly depicted RA activity.https://mrj.ima-press.net/mrj/article/view/1270rheumatoid arthritisalbuminfibrinogenc-reactive protein |
| spellingShingle | Elsabagh Abdou Amira Abd-Elwahab Selim Heba Mohamed Mohyeldin Amany Ahmed Hany Marwa C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients Современная ревматология rheumatoid arthritis albumin fibrinogen c-reactive protein |
| title | C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients |
| title_full | C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients |
| title_fullStr | C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients |
| title_full_unstemmed | C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients |
| title_short | C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients |
| title_sort | c reactive protein to albumin ratio and albumin to fibrinogen ratio in rheumatoid arthritis patients |
| topic | rheumatoid arthritis albumin fibrinogen c-reactive protein |
| url | https://mrj.ima-press.net/mrj/article/view/1270 |
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