Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment
Ubiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life. E3 ubiquitin ligases specifically recognize substrate proteins during ubiquitin modification, regulating intracell...
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| Format: | Article |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618424/full |
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| _version_ | 1849235188080443392 |
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| author | Kun Zhang Hui Yuan Lin Shi |
| author_facet | Kun Zhang Hui Yuan Lin Shi |
| author_sort | Kun Zhang |
| collection | DOAJ |
| description | Ubiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life. E3 ubiquitin ligases specifically recognize substrate proteins during ubiquitin modification, regulating intracellular protein levels and functions through the ubiquitin-proteasome pathway or TGF-β signal transduction. In recent years, substantial evidence has emerged, emphasizing the pivotal role that E3 ubiquitin ligases play in the development of pulmonary fibrosis. Advancing our understanding of how E3 ubiquitin ligases interact with pulmonary fibrosis could reveal new therapeutic targets and treatments for idiopathic pulmonary fibrosis (IPF), as well as innovative approaches in diagnosis and therapy. This review explores known regulatory mechanisms and identifies E3 ligases that have been implicated in IPF development. |
| format | Article |
| id | doaj-art-ef75b6b825cc45f6b8eb8f4c001cdf71 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ef75b6b825cc45f6b8eb8f4c001cdf712025-08-20T04:02:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16184241618424Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatmentKun ZhangHui YuanLin ShiUbiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life. E3 ubiquitin ligases specifically recognize substrate proteins during ubiquitin modification, regulating intracellular protein levels and functions through the ubiquitin-proteasome pathway or TGF-β signal transduction. In recent years, substantial evidence has emerged, emphasizing the pivotal role that E3 ubiquitin ligases play in the development of pulmonary fibrosis. Advancing our understanding of how E3 ubiquitin ligases interact with pulmonary fibrosis could reveal new therapeutic targets and treatments for idiopathic pulmonary fibrosis (IPF), as well as innovative approaches in diagnosis and therapy. This review explores known regulatory mechanisms and identifies E3 ligases that have been implicated in IPF development.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618424/fullidiopathic pulmonary fibrosisE3 ubiquitin ligasetransforming growth factor-βepithelial-mesenchymal transitionprofibrotic fibroblast |
| spellingShingle | Kun Zhang Hui Yuan Lin Shi Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment Frontiers in Immunology idiopathic pulmonary fibrosis E3 ubiquitin ligase transforming growth factor-β epithelial-mesenchymal transition profibrotic fibroblast |
| title | Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment |
| title_full | Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment |
| title_fullStr | Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment |
| title_full_unstemmed | Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment |
| title_short | Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment |
| title_sort | targeting e3 ubiquitin ligases a new frontier in idiopathic pulmonary fibrosis treatment |
| topic | idiopathic pulmonary fibrosis E3 ubiquitin ligase transforming growth factor-β epithelial-mesenchymal transition profibrotic fibroblast |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618424/full |
| work_keys_str_mv | AT kunzhang targetinge3ubiquitinligasesanewfrontierinidiopathicpulmonaryfibrosistreatment AT huiyuan targetinge3ubiquitinligasesanewfrontierinidiopathicpulmonaryfibrosistreatment AT linshi targetinge3ubiquitinligasesanewfrontierinidiopathicpulmonaryfibrosistreatment |