Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients
Introduction: The workload of physicians increased due to the number of patients presenting with suspicion of coronavirus 2019 (COVID-19) and the prolonged wait times in the emergency department during the COVID-19 pandemic. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) is a protein p...
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| Format: | Article |
| Language: | English |
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eScholarship Publishing, University of California
2024-10-01
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| Series: | Western Journal of Emergency Medicine |
| Online Access: | https://escholarship.org/uc/item/2z7033t5 |
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| author | Vildan Ozer Ozgen Gonenc Cekic Ozlem Bulbul Davut Aydın Eser Bulut Firdevs Aksoy Mehtap Pehlivanlar Kucuk Suleyman Caner Karahan Ebru Emel Sozen Esra Ozkaya Polat Kosucu Yunus Karaca Suleyman Turedi |
| author_facet | Vildan Ozer Ozgen Gonenc Cekic Ozlem Bulbul Davut Aydın Eser Bulut Firdevs Aksoy Mehtap Pehlivanlar Kucuk Suleyman Caner Karahan Ebru Emel Sozen Esra Ozkaya Polat Kosucu Yunus Karaca Suleyman Turedi |
| author_sort | Vildan Ozer |
| collection | DOAJ |
| description | Introduction: The workload of physicians increased due to the number of patients presenting with suspicion of coronavirus 2019 (COVID-19) and the prolonged wait times in the emergency department during the COVID-19 pandemic. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) is a protein present in platelets and endothelial cells; it is activated by inflammation from COVID-19 and may be associated with COVID-19’s known thrombotic risk. We aimed to determine whether SCUBE-1 levels are diagnostically correlated in suspected COVID-19 patients, and whether SCUBE-1 correlated with severity of disease and, therefore, might be useful to guide hospitalization/discharge decisions. Methods: The suspected COVID-19 patients cared for at tertiary healthcare institutions for one year between May 2021–May 2022 were examined in this study. The subjects were both suspected COVID-19 patients not ultimately found to have COVID-19 and those who were diagnosed with COVID-19. By modifying the disease severity scoring systems present in COVID-19 guidelines in 2021, the COVID-19-positive patient group was classified as mild, moderate, severe, and critical, and compared using the SCUBE-1 levels. Moreover, SCUBE-1 levels were compared between the COVID-19 positive group and the COVID-19 negative group. Results: A total of 507 patients were considered for the present study. After excluding 175 patients for incomplete data and alternate comorbid organ failure. we report on 332 patients (65.5%). Of these 332 patients, 80 (24.0%) were COVID-19 negative, and 252 (76.0%) were COVID-19 positive. Of 252 (100%) patients diagnosed with COVID-19, 74 (29.4%) were classified as mild, 95 (37.7%) moderate, 45 (17.8%) severe, and 38 (15.1%) critical. The SCUBE-1 levels were statistically different between COVID-19 positive (8.48 ± 7.42 nanograms per milliliter [ng/mL]) and COVID-19 negative (1.86 ± 0.92 ng/mL) patients (P < 0.001). In the COVID-19 positive group, SCUBE-1 levels increased with disease severity (mild = 3.20 ± 1.65 ng/mL, moderate = 4.78 ± 2.26 ng/mL, severe = 13.68 ± 3.95 ng/mL, and critical = 21.87 ± 5.39 ng/mL) (P < 0.001). The initial SCUBE-1 levels of discharged patients were significantly lower than those requiring hospitalization (discharged = 2.89 ng/mL [0.55–8.60 ng/mL]; ward admitted = 7.13 ng/mL [1.38–21.29 ng/mL], and ICU admitted = 21.19 ng/mL [10.58–37.86 ng/mL]) (P < 0.001). Conclusion: The SCUBE-1 levels were found to be differentiated between patients with and without COVID-19 and to be correlated with the severity of illness. |
| format | Article |
| id | doaj-art-ef73699752c8478ab093581a907c731d |
| institution | DOAJ |
| issn | 1936-900X 1936-9018 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | eScholarship Publishing, University of California |
| record_format | Article |
| series | Western Journal of Emergency Medicine |
| spelling | doaj-art-ef73699752c8478ab093581a907c731d2025-08-20T02:50:36ZengeScholarship Publishing, University of CaliforniaWestern Journal of Emergency Medicine1936-900X1936-90182024-10-0125697598410.5811/westjem.1858618586Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 PatientsVildan Ozer0Ozgen Gonenc Cekic1Ozlem Bulbul2Davut Aydın3Eser Bulut4Firdevs Aksoy5Mehtap Pehlivanlar Kucuk6Suleyman Caner Karahan7Ebru Emel Sozen8Esra Ozkaya9Polat Kosucu10Yunus Karaca11Suleyman Turedi12Karadeniz Technical University, School of Medicine, Department of Emergency Medicine, Trabzon, TürkiyeSBU Kanuni Training and Research Hospital, Department of Emergency Medicine, Trabzon, TürkiyeKaradeniz Technical University, School of Medicine, Department of Emergency Medicine, Trabzon, TürkiyeSBU Kanuni Training and Research Hospital, Department of Chest Diseases, Division of Intensive Care Medicine, Trabzon, TürkiyeSBU Kanuni Training and Research Hospital, Department of Radiology, Trabzon, TürkiyeKaradeniz Technical University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, TürkiyeKaradeniz Technical University, School of Medicine, Department of Chest Diseases, Division of Intensive Care Medicine, Trabzon, TürkiyeKaradeniz Technical University, School of Medicine, Department of Biochemistry, Trabzon, TürkiyeSBU Kanuni Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Trabzon, TürkiyeKaradeniz Technical University, School of Medicine, Department of Medical Microbiology, Trabzon, TürkiyeKaradeniz Technical University, School of Medicine, Department of Radiology, Trabzon, TürkiyeKaradeniz Technical University, School of Medicine, Department of Emergency Medicine, Trabzon, TürkiyeSBU Kanuni Training and Research Hospital, Department of Emergency Medicine, Trabzon, TürkiyeIntroduction: The workload of physicians increased due to the number of patients presenting with suspicion of coronavirus 2019 (COVID-19) and the prolonged wait times in the emergency department during the COVID-19 pandemic. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) is a protein present in platelets and endothelial cells; it is activated by inflammation from COVID-19 and may be associated with COVID-19’s known thrombotic risk. We aimed to determine whether SCUBE-1 levels are diagnostically correlated in suspected COVID-19 patients, and whether SCUBE-1 correlated with severity of disease and, therefore, might be useful to guide hospitalization/discharge decisions. Methods: The suspected COVID-19 patients cared for at tertiary healthcare institutions for one year between May 2021–May 2022 were examined in this study. The subjects were both suspected COVID-19 patients not ultimately found to have COVID-19 and those who were diagnosed with COVID-19. By modifying the disease severity scoring systems present in COVID-19 guidelines in 2021, the COVID-19-positive patient group was classified as mild, moderate, severe, and critical, and compared using the SCUBE-1 levels. Moreover, SCUBE-1 levels were compared between the COVID-19 positive group and the COVID-19 negative group. Results: A total of 507 patients were considered for the present study. After excluding 175 patients for incomplete data and alternate comorbid organ failure. we report on 332 patients (65.5%). Of these 332 patients, 80 (24.0%) were COVID-19 negative, and 252 (76.0%) were COVID-19 positive. Of 252 (100%) patients diagnosed with COVID-19, 74 (29.4%) were classified as mild, 95 (37.7%) moderate, 45 (17.8%) severe, and 38 (15.1%) critical. The SCUBE-1 levels were statistically different between COVID-19 positive (8.48 ± 7.42 nanograms per milliliter [ng/mL]) and COVID-19 negative (1.86 ± 0.92 ng/mL) patients (P < 0.001). In the COVID-19 positive group, SCUBE-1 levels increased with disease severity (mild = 3.20 ± 1.65 ng/mL, moderate = 4.78 ± 2.26 ng/mL, severe = 13.68 ± 3.95 ng/mL, and critical = 21.87 ± 5.39 ng/mL) (P < 0.001). The initial SCUBE-1 levels of discharged patients were significantly lower than those requiring hospitalization (discharged = 2.89 ng/mL [0.55–8.60 ng/mL]; ward admitted = 7.13 ng/mL [1.38–21.29 ng/mL], and ICU admitted = 21.19 ng/mL [10.58–37.86 ng/mL]) (P < 0.001). Conclusion: The SCUBE-1 levels were found to be differentiated between patients with and without COVID-19 and to be correlated with the severity of illness.https://escholarship.org/uc/item/2z7033t5 |
| spellingShingle | Vildan Ozer Ozgen Gonenc Cekic Ozlem Bulbul Davut Aydın Eser Bulut Firdevs Aksoy Mehtap Pehlivanlar Kucuk Suleyman Caner Karahan Ebru Emel Sozen Esra Ozkaya Polat Kosucu Yunus Karaca Suleyman Turedi Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients Western Journal of Emergency Medicine |
| title | Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients |
| title_full | Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients |
| title_fullStr | Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients |
| title_full_unstemmed | Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients |
| title_short | Diagnostic and Prognostic Value of SCUBE-1 in COVID-19 Patients |
| title_sort | diagnostic and prognostic value of scube 1 in covid 19 patients |
| url | https://escholarship.org/uc/item/2z7033t5 |
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