Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction
Drug delivery systems (DDSs) have been developed to carry an appropriate payload into the tumour’s area, accomplishing the goals of minimising potential bodily harm and enhancing therapeutic efficacy. Here, we fabricated a one-pot method for encasing docetaxel (DTX) in zeolitic imidazolate framework...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Experimental Nanoscience |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/17458080.2024.2307061 |
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| author | Shuyi Wu Henghua Li Di Su Na Lu |
| author_facet | Shuyi Wu Henghua Li Di Su Na Lu |
| author_sort | Shuyi Wu |
| collection | DOAJ |
| description | Drug delivery systems (DDSs) have been developed to carry an appropriate payload into the tumour’s area, accomplishing the goals of minimising potential bodily harm and enhancing therapeutic efficacy. Here, we fabricated a one-pot method for encasing docetaxel (DTX) in zeolitic imidazolate framework-8 (ZIF-8) composites called DTX@ZIF-8. The DTX@ZIF-8/HA nanoplatform is then formed by coating the DTX@HA with a hyaluronic acid (HA). Notably, the loading rate increased to 43.0% at a DTX dose of 1 mg/mL. The findings confirmed that HA could prolong blood flow and improve the tumour-specific formation of DDS. It may also be an innovative ‘switch’ and tumour-targeted ‘guider’. Hyaluronidase (HAase) in the tumour microenvironment (TME) may break down the HA shell, exposing the wrapped DTX@ZIF-8 and causing ZIF-8 to break down in the acidic tumour microenvironment, releasing the loaded DTX. The apoptosis mechanism was investigated using various biochemical staining and flow cytometric analysis. As a result, the DTX@ZIF-8/HA nanoplatforms were developed as an on-demand, tumour-specific drug delivery system, increasing the effectiveness of treatment. |
| format | Article |
| id | doaj-art-ef6f14746f274e6583339df7c4a522fc |
| institution | DOAJ |
| issn | 1745-8080 1745-8099 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Experimental Nanoscience |
| spelling | doaj-art-ef6f14746f274e6583339df7c4a522fc2025-08-20T02:48:43ZengTaylor & Francis GroupJournal of Experimental Nanoscience1745-80801745-80992024-12-0119110.1080/17458080.2024.2307061Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis inductionShuyi Wu0Henghua Li1Di Su2Na Lu3Institute of Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica, Chongqing, ChinaInstitute of Pharmacology and Toxicology, Chongqing Academy of Chinese Materia Medica, Chongqing, ChinaBasic Medical College, Chongqing Medical University, Chongqing, ChinaBasic Medical College, Chongqing Medical University, Chongqing, ChinaDrug delivery systems (DDSs) have been developed to carry an appropriate payload into the tumour’s area, accomplishing the goals of minimising potential bodily harm and enhancing therapeutic efficacy. Here, we fabricated a one-pot method for encasing docetaxel (DTX) in zeolitic imidazolate framework-8 (ZIF-8) composites called DTX@ZIF-8. The DTX@ZIF-8/HA nanoplatform is then formed by coating the DTX@HA with a hyaluronic acid (HA). Notably, the loading rate increased to 43.0% at a DTX dose of 1 mg/mL. The findings confirmed that HA could prolong blood flow and improve the tumour-specific formation of DDS. It may also be an innovative ‘switch’ and tumour-targeted ‘guider’. Hyaluronidase (HAase) in the tumour microenvironment (TME) may break down the HA shell, exposing the wrapped DTX@ZIF-8 and causing ZIF-8 to break down in the acidic tumour microenvironment, releasing the loaded DTX. The apoptosis mechanism was investigated using various biochemical staining and flow cytometric analysis. As a result, the DTX@ZIF-8/HA nanoplatforms were developed as an on-demand, tumour-specific drug delivery system, increasing the effectiveness of treatment.https://www.tandfonline.com/doi/10.1080/17458080.2024.2307061Apoptosisdocetaxeldrug delivery systemshyaluronic acidleukaemia cancerzeolitic imidazolate framework-8 |
| spellingShingle | Shuyi Wu Henghua Li Di Su Na Lu Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction Journal of Experimental Nanoscience Apoptosis docetaxel drug delivery systems hyaluronic acid leukaemia cancer zeolitic imidazolate framework-8 |
| title | Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction |
| title_full | Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction |
| title_fullStr | Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction |
| title_full_unstemmed | Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction |
| title_short | Fabrication of docetaxel-loaded hyaluronic acid coated zeolitic imidazolate framework‑8 as an effective treatment for leukaemia cancer cells and its apoptosis induction |
| title_sort | fabrication of docetaxel loaded hyaluronic acid coated zeolitic imidazolate framework 8 as an effective treatment for leukaemia cancer cells and its apoptosis induction |
| topic | Apoptosis docetaxel drug delivery systems hyaluronic acid leukaemia cancer zeolitic imidazolate framework-8 |
| url | https://www.tandfonline.com/doi/10.1080/17458080.2024.2307061 |
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