Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation
Background: Proteus mirabilis, an important uropathogen that can cause complicated urinary tract infections (UTI), has emerged as a therapeutic problem following mutations that compromise the use of antimicrobial drugs. Due to the serious effects associated with uropathogenic P. mirabilis and the p...
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The Journal of Infection in Developing Countries
2009-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/232 |
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| author | Vanessa Sosa Pablo Zunino |
| author_facet | Vanessa Sosa Pablo Zunino |
| author_sort | Vanessa Sosa |
| collection | DOAJ |
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Background: Proteus mirabilis, an important uropathogen that can cause complicated urinary tract infections (UTI), has emerged as a therapeutic problem following mutations that compromise the use of antimicrobial drugs. Due to the serious effects associated with uropathogenic P. mirabilis and the problems related to the use of antibiotics, it is necessary to develop alternative strategies for its control. The objective of this study was to assess the effect of Ibicella lutea extract, a South American indigenous plant, on growth, virulence and biofilm production of uropathogenic P. mirabilis.
Methodology: This study was based on the extract generation and the assessment of its effect on bacterial features related to virulence. These assays involved determination of antibacterial activity, swarming motility, Western blot to assess expression of fimbriae and flagella, biofilms formation, haemagglutination, haemolysis, and electron microscopy.
Results and Conclusions: I. lutea extract had an effect on bacterial growth rate and bacterial morphology. It also affected P. mirabilis swarming differentiation, hemagglutination and biofilm formation on glass and polystyrene. These findings suggest that I. lutea may have a role as an agent for the control of P. mirabilis UTI.
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| format | Article |
| id | doaj-art-ef6ce7439f7e47afb60848f6a4e5b62d |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2009-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ef6ce7439f7e47afb60848f6a4e5b62d2025-08-20T02:57:16ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-11-0131010.3855/jidc.232Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formationVanessa Sosa0Pablo Zunino1Departamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Avenida Italia 3318, CP11600, MontevideoDepartamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Avenida Italia 3318, CP11600, Montevideo Background: Proteus mirabilis, an important uropathogen that can cause complicated urinary tract infections (UTI), has emerged as a therapeutic problem following mutations that compromise the use of antimicrobial drugs. Due to the serious effects associated with uropathogenic P. mirabilis and the problems related to the use of antibiotics, it is necessary to develop alternative strategies for its control. The objective of this study was to assess the effect of Ibicella lutea extract, a South American indigenous plant, on growth, virulence and biofilm production of uropathogenic P. mirabilis. Methodology: This study was based on the extract generation and the assessment of its effect on bacterial features related to virulence. These assays involved determination of antibacterial activity, swarming motility, Western blot to assess expression of fimbriae and flagella, biofilms formation, haemagglutination, haemolysis, and electron microscopy. Results and Conclusions: I. lutea extract had an effect on bacterial growth rate and bacterial morphology. It also affected P. mirabilis swarming differentiation, hemagglutination and biofilm formation on glass and polystyrene. These findings suggest that I. lutea may have a role as an agent for the control of P. mirabilis UTI. https://jidc.org/index.php/journal/article/view/232Ibicella luteaPreventionProteus mirabilisUrinary tract infectionVegetal extract |
| spellingShingle | Vanessa Sosa Pablo Zunino Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation Journal of Infection in Developing Countries Ibicella lutea Prevention Proteus mirabilis Urinary tract infection Vegetal extract |
| title | Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation |
| title_full | Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation |
| title_fullStr | Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation |
| title_full_unstemmed | Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation |
| title_short | Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation |
| title_sort | effect of ibicella lutea on uropathogenic proteus mirabilis growth virulence and biofilm formation |
| topic | Ibicella lutea Prevention Proteus mirabilis Urinary tract infection Vegetal extract |
| url | https://jidc.org/index.php/journal/article/view/232 |
| work_keys_str_mv | AT vanessasosa effectofibicellaluteaonuropathogenicproteusmirabilisgrowthvirulenceandbiofilmformation AT pablozunino effectofibicellaluteaonuropathogenicproteusmirabilisgrowthvirulenceandbiofilmformation |