Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review
This systematic review assessed the global epidemiology of metallo-β-lactamase (MBL)-producing <i>Acinetobacter</i> clinical isolates and the associated antimicrobial resistance. A total of 475 relevant articles from the Cochrane Library, Google Scholar, PubMed, Scopus, and Web of Scienc...
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2025-06-01
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| author | Matthew E. Falagas Dimitrios S. Kontogiannis Maria Zidrou Charalampos Filippou Giannoula S. Tansarli |
| author_facet | Matthew E. Falagas Dimitrios S. Kontogiannis Maria Zidrou Charalampos Filippou Giannoula S. Tansarli |
| author_sort | Matthew E. Falagas |
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| description | This systematic review assessed the global epidemiology of metallo-β-lactamase (MBL)-producing <i>Acinetobacter</i> clinical isolates and the associated antimicrobial resistance. A total of 475 relevant articles from the Cochrane Library, Google Scholar, PubMed, Scopus, and Web of Science were identified and screened as potentially eligible articles. Data from 85 articles were extracted for the analysis. Most reports on MBL-producing <i>Acinetobacter</i> clinical isolates originated from Asia [68/85 (80%) studies] and Africa [14/85 (16.5%) studies]. There were also scarce reports from Europe and America. The <i>bla</i><sub>VIM</sub> (in 31 studies), <i>bla</i><sub>IMP</sub> (in 29 studies), and <i>bla</i><sub>NDM</sub> (in 21 studies) genes were the most commonly identified genes. In 22 out of 28 (78.6%) studies with comparable data, the proportions of MBL-producing pathogens detected using phenotypic methods were numerically higher than those using genotypic methods. MBL-producing <i>Acinetobacter</i> isolates showed high resistance (up to 100%) to several antibiotic classes, including carbapenems, cephalosporins, fluoroquinolones, and monobactams. However, they showed low resistance to colistin [ranging from 0% (in six studies) to 14.3% (in one study)] and to tigecycline [0% (in three studies)]. No risk of bias assessment was conducted. The findings emphasize the global spread of MBL-producing <i>Acinetobacter</i> and the need for enhanced antimicrobial stewardship, infection control measures, and surveillance. |
| format | Article |
| id | doaj-art-ef6b7813e9c84cc7a9e03280aa6ecd89 |
| institution | OA Journals |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Pathogens |
| spelling | doaj-art-ef6b7813e9c84cc7a9e03280aa6ecd892025-08-20T02:21:49ZengMDPI AGPathogens2076-08172025-06-0114655710.3390/pathogens14060557Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic ReviewMatthew E. Falagas0Dimitrios S. Kontogiannis1Maria Zidrou2Charalampos Filippou3Giannoula S. Tansarli4Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23 Marousi, Athens, GreeceAlfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23 Marousi, Athens, GreeceAlfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23 Marousi, Athens, GreeceSchool of Medicine, European University Cyprus, 2404 Nicosia, CyprusDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USAThis systematic review assessed the global epidemiology of metallo-β-lactamase (MBL)-producing <i>Acinetobacter</i> clinical isolates and the associated antimicrobial resistance. A total of 475 relevant articles from the Cochrane Library, Google Scholar, PubMed, Scopus, and Web of Science were identified and screened as potentially eligible articles. Data from 85 articles were extracted for the analysis. Most reports on MBL-producing <i>Acinetobacter</i> clinical isolates originated from Asia [68/85 (80%) studies] and Africa [14/85 (16.5%) studies]. There were also scarce reports from Europe and America. The <i>bla</i><sub>VIM</sub> (in 31 studies), <i>bla</i><sub>IMP</sub> (in 29 studies), and <i>bla</i><sub>NDM</sub> (in 21 studies) genes were the most commonly identified genes. In 22 out of 28 (78.6%) studies with comparable data, the proportions of MBL-producing pathogens detected using phenotypic methods were numerically higher than those using genotypic methods. MBL-producing <i>Acinetobacter</i> isolates showed high resistance (up to 100%) to several antibiotic classes, including carbapenems, cephalosporins, fluoroquinolones, and monobactams. However, they showed low resistance to colistin [ranging from 0% (in six studies) to 14.3% (in one study)] and to tigecycline [0% (in three studies)]. No risk of bias assessment was conducted. The findings emphasize the global spread of MBL-producing <i>Acinetobacter</i> and the need for enhanced antimicrobial stewardship, infection control measures, and surveillance.https://www.mdpi.com/2076-0817/14/6/557<i>Acinetobacter</i>β-lactamaseantimicrobial resistancemetallo-β-lactamaseNew Delhi metallo-β-lactamase (NDM)imipenemase metallo-β-lactamase (IMP) |
| spellingShingle | Matthew E. Falagas Dimitrios S. Kontogiannis Maria Zidrou Charalampos Filippou Giannoula S. Tansarli Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review Pathogens <i>Acinetobacter</i> β-lactamase antimicrobial resistance metallo-β-lactamase New Delhi metallo-β-lactamase (NDM) imipenemase metallo-β-lactamase (IMP) |
| title | Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review |
| title_full | Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review |
| title_fullStr | Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review |
| title_full_unstemmed | Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review |
| title_short | Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review |
| title_sort | global epidemiology and antimicrobial resistance of metallo β lactamase mbl producing acinetobacter clinical isolates a systematic review |
| topic | <i>Acinetobacter</i> β-lactamase antimicrobial resistance metallo-β-lactamase New Delhi metallo-β-lactamase (NDM) imipenemase metallo-β-lactamase (IMP) |
| url | https://www.mdpi.com/2076-0817/14/6/557 |
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