Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)
Random copolymers of poly(d,l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) were synthesized by the ring-opening polymerization of d,l-lactide (DLLA), glycolide (GA), and ε-caprolactone (CL). The effects of CL on the copolymers were evaluated to prepare suitable copolymers with controlled propertie...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2016/8082014 |
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| author | Yixiu Liu Xizhuang Bai A. Liang |
| author_facet | Yixiu Liu Xizhuang Bai A. Liang |
| author_sort | Yixiu Liu |
| collection | DOAJ |
| description | Random copolymers of poly(d,l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) were synthesized by the ring-opening polymerization of d,l-lactide (DLLA), glycolide (GA), and ε-caprolactone (CL). The effects of CL on the copolymers were evaluated to prepare suitable copolymers with controlled properties. Our results showed that the CL content significantly influenced the thermal and mechanical properties of the copolymers and that the CL content in compositions could be altered to control properties of random copolymers. The in vitro hydrolytic degradation of the resulting implants showed that the degradation rate of PLGC was lower than that of PLGA, which could markedly reduce acidic degradation products. Finally, we demonstrated that higher CL contents in compositions slowed degradation rates. |
| format | Article |
| id | doaj-art-ef68de48c8ea4d74a916d1fa0a77e8bc |
| institution | OA Journals |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-ef68de48c8ea4d74a916d1fa0a77e8bc2025-08-20T02:22:24ZengWileyInternational Journal of Polymer Science1687-94221687-94302016-01-01201610.1155/2016/80820148082014Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)Yixiu Liu0Xizhuang Bai1A. Liang2Department of Sports Medicine and Joint Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Sports Medicine and Joint Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Orthopaedics, The Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, ChinaRandom copolymers of poly(d,l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) were synthesized by the ring-opening polymerization of d,l-lactide (DLLA), glycolide (GA), and ε-caprolactone (CL). The effects of CL on the copolymers were evaluated to prepare suitable copolymers with controlled properties. Our results showed that the CL content significantly influenced the thermal and mechanical properties of the copolymers and that the CL content in compositions could be altered to control properties of random copolymers. The in vitro hydrolytic degradation of the resulting implants showed that the degradation rate of PLGC was lower than that of PLGA, which could markedly reduce acidic degradation products. Finally, we demonstrated that higher CL contents in compositions slowed degradation rates.http://dx.doi.org/10.1155/2016/8082014 |
| spellingShingle | Yixiu Liu Xizhuang Bai A. Liang Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone) International Journal of Polymer Science |
| title | Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone) |
| title_full | Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone) |
| title_fullStr | Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone) |
| title_full_unstemmed | Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone) |
| title_short | Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone) |
| title_sort | synthesis properties and in vitro hydrolytic degradation of poly d l lactide co glycolide co ε caprolactone |
| url | http://dx.doi.org/10.1155/2016/8082014 |
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