The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023)
Abstract Background The Coronavirus Disease 2019 (COVID-19) pandemic precipitated an urgent need for clinical trials to discover safe and efficacious treatments. We examined how COVID-19 experiences, clinical trial awareness, and trust in the vaccine safety process were associated with willingness t...
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| Format: | Article |
| Language: | English |
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BMC
2024-07-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-19602-7 |
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| author | Hyunmin Yu José Bauermeister Ufuoma Oyiborhoro Knashawn Morales Subhash Aryal Karen Glanz Antonia Villarruel Stephen Bonett |
| author_facet | Hyunmin Yu José Bauermeister Ufuoma Oyiborhoro Knashawn Morales Subhash Aryal Karen Glanz Antonia Villarruel Stephen Bonett |
| author_sort | Hyunmin Yu |
| collection | DOAJ |
| description | Abstract Background The Coronavirus Disease 2019 (COVID-19) pandemic precipitated an urgent need for clinical trials to discover safe and efficacious treatments. We examined how COVID-19 experiences, clinical trial awareness, and trust in the vaccine safety process were associated with willingness to participate in COVID-19 clinical trials. The objective was to investigate the relationship between trust in federal oversight of vaccine safety and willingness to participate in clinical trials for COVID-19 treatment across four distinct time points over an 18-month period during the COVID-19 pandemic. Methods We used four waves of data collected from September 2021 to March 2023 among 582 Philadelphia residents (with a missing data rate of 0.9%). Generalized estimating equations estimated the association between willingness to participate in COVID-19 clinical trials and participants’ trust in the federal government’s oversight of COVID-19 vaccine safety, COVID-19-related variables (COVID-19 related health challenges, history of COVID-19 infection), awareness of clinical trials and how to enroll in them, and sociodemographic characteristics (age, race/ethnicity, sexual orientation, gender, parental status, education, and insurance). Results On average, willingness to participate in a COVID-19 clinical trial was positively associated with greater trust in the federal government’s oversight of vaccine safety [β = 0.34, 95% confidence interval (CI): 0.15–0.53], having COVID-19 (β = 0.40, 95% CI: 0.08–0.73), awareness of clinical trials (β = 0.38, 95% CI: 0.04–0.73), and knowledge of how to enroll (β = 0.83, 95% CI: 0.44–1.23). Among sociodemographic characteristics, race/ethnicity (p = 0.001) and gender (p = 0.018) were identified as predictors for COVID-19 trial willingness. Conclusion Willingness to participate in clinical trials may be bolstered by strengthening the public’s trust in the federal government’s role within vaccine safety oversight, increasing the perceived relevance of clinical trials to individuals’ health and well-being, and offering tailored information to educate diverse communities about ongoing trials and how to enroll in them. |
| format | Article |
| id | doaj-art-ef63207c0c7a461898a106dd061135b7 |
| institution | OA Journals |
| issn | 1471-2458 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-ef63207c0c7a461898a106dd061135b72025-08-20T02:20:02ZengBMCBMC Public Health1471-24582024-07-0124111010.1186/s12889-024-19602-7The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023)Hyunmin Yu0José Bauermeister1Ufuoma Oyiborhoro2Knashawn Morales3Subhash Aryal4Karen Glanz5Antonia Villarruel6Stephen Bonett7School of Nursing, University of PennsylvaniaSchool of Nursing, University of PennsylvaniaSchool of Nursing, University of PennsylvaniaPerelman School of Medicine, University of PennsylvaniaSchool of Nursing, Johns Hopkins UniversitySchool of Nursing, University of PennsylvaniaSchool of Nursing, University of PennsylvaniaSchool of Nursing, University of PennsylvaniaAbstract Background The Coronavirus Disease 2019 (COVID-19) pandemic precipitated an urgent need for clinical trials to discover safe and efficacious treatments. We examined how COVID-19 experiences, clinical trial awareness, and trust in the vaccine safety process were associated with willingness to participate in COVID-19 clinical trials. The objective was to investigate the relationship between trust in federal oversight of vaccine safety and willingness to participate in clinical trials for COVID-19 treatment across four distinct time points over an 18-month period during the COVID-19 pandemic. Methods We used four waves of data collected from September 2021 to March 2023 among 582 Philadelphia residents (with a missing data rate of 0.9%). Generalized estimating equations estimated the association between willingness to participate in COVID-19 clinical trials and participants’ trust in the federal government’s oversight of COVID-19 vaccine safety, COVID-19-related variables (COVID-19 related health challenges, history of COVID-19 infection), awareness of clinical trials and how to enroll in them, and sociodemographic characteristics (age, race/ethnicity, sexual orientation, gender, parental status, education, and insurance). Results On average, willingness to participate in a COVID-19 clinical trial was positively associated with greater trust in the federal government’s oversight of vaccine safety [β = 0.34, 95% confidence interval (CI): 0.15–0.53], having COVID-19 (β = 0.40, 95% CI: 0.08–0.73), awareness of clinical trials (β = 0.38, 95% CI: 0.04–0.73), and knowledge of how to enroll (β = 0.83, 95% CI: 0.44–1.23). Among sociodemographic characteristics, race/ethnicity (p = 0.001) and gender (p = 0.018) were identified as predictors for COVID-19 trial willingness. Conclusion Willingness to participate in clinical trials may be bolstered by strengthening the public’s trust in the federal government’s role within vaccine safety oversight, increasing the perceived relevance of clinical trials to individuals’ health and well-being, and offering tailored information to educate diverse communities about ongoing trials and how to enroll in them.https://doi.org/10.1186/s12889-024-19602-7Clinical trial participationCOVID-19 pandemicTrustFederal oversightGovernment regulation |
| spellingShingle | Hyunmin Yu José Bauermeister Ufuoma Oyiborhoro Knashawn Morales Subhash Aryal Karen Glanz Antonia Villarruel Stephen Bonett The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023) BMC Public Health Clinical trial participation COVID-19 pandemic Trust Federal oversight Government regulation |
| title | The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023) |
| title_full | The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023) |
| title_fullStr | The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023) |
| title_full_unstemmed | The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023) |
| title_short | The relationship between trust in federal oversight of vaccine safety and willingness to participate in COVID-19 clinical trials: a repeated measures study of Philadelphia residents (September 2021 – March 2023) |
| title_sort | relationship between trust in federal oversight of vaccine safety and willingness to participate in covid 19 clinical trials a repeated measures study of philadelphia residents september 2021 march 2023 |
| topic | Clinical trial participation COVID-19 pandemic Trust Federal oversight Government regulation |
| url | https://doi.org/10.1186/s12889-024-19602-7 |
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