Determination of protective effectiveness of nerium oleander distillation in doxorubicin-induced organ damages
<b>Aim:</b> The aim of this study was to investigate that effect of Nerium oleander (NO) distillate on doxorubicin-induced oxidative damage and other side effects.<p> <b>Materials and Methods:</b> NO leaves were collected, distillated and lyophilized. In the current res...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1032 |
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| Summary: | <b>Aim:</b> The aim of this study was to investigate that effect of Nerium
oleander (NO) distillate on doxorubicin-induced oxidative
damage and other side effects.<p>
<b>Materials and Methods:</b> NO leaves were collected, distillated
and lyophilized. In the current research, 28 rats were divided
into 4 groups; Control, Doxorubicin (3 mg/kg, every other day,
intraperitoneally), NO (1 mg/kg, SID, PO) and Doxorubicin (3
mg/kg, every other day, intraperitoneally) + NO (1 mg/kg, SID,
PO). All treatments were performed 11 days. At 24 hours after
the last administration, blood samples were taken from the
hearts under general anesthetizes, and euthanized immediately.
Also, heart, liver and kidney were taken and homogenized. Tissue
thiobarbituric acid reactive substances (TBARS) levels, serum
biochemical and hemogram values were measured by ELISA,
autoanalyzer and blood cell counter, respectively.<p>
<b>Results:</b> Heart TBARS values of the doxorubicin group were
lower (P<0.05) than Doxorubicin + NO distillate group, while
kidney TBARS values of the doxorubicin group were higher
(P<0.05) than the NO distillate group. Although doxorubicin decreased
(P<0.05) blood cell counts, hemoglobin and hematocrit
levels compared to Control group, administration of doxorubicin
+ NO distillate ameliorated only hematocrit levels. Doxorubicin
decreased (P<0.05) serum total protein and albumin levels
compared to Control group, while Doxorubicin + NO distillate
increased (P<0.05) aspartate aminotransferase and blood urea
nitrogen levels and decreased (P<0.05) total protein, albumin
and creatinine levels.<p>
<b>Conclusions:</b> It may be stated that levels of NO distillate used
in the current research do not prevent the doxorubicin caused
side effects. |
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| ISSN: | 1309-6958 2146-1953 |