Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review
Introduction. The triglyceride and glucose (TyG) index has been described as a biochemical marker of insulin resistance (IR); however, its diagnostic accuracy remains uncertain. Objective. To summarize the evidence assessing the diagnostic accuracy of the TyG index regarding IR. Methods. A comprehen...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/4678526 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568609105248256 |
|---|---|
| author | Adriana Sánchez-García René Rodríguez-Gutiérrez Leonardo Mancillas-Adame Victoria González-Nava Alejandro Díaz González-Colmenero Ricardo Cesar Solis Neri Alejandro Álvarez-Villalobos José Gerardo González-González |
| author_facet | Adriana Sánchez-García René Rodríguez-Gutiérrez Leonardo Mancillas-Adame Victoria González-Nava Alejandro Díaz González-Colmenero Ricardo Cesar Solis Neri Alejandro Álvarez-Villalobos José Gerardo González-González |
| author_sort | Adriana Sánchez-García |
| collection | DOAJ |
| description | Introduction. The triglyceride and glucose (TyG) index has been described as a biochemical marker of insulin resistance (IR); however, its diagnostic accuracy remains uncertain. Objective. To summarize the evidence assessing the diagnostic accuracy of the TyG index regarding IR. Methods. A comprehensive search in MEDLINE, EMBASE, Web of Science, and Scopus was performed without any language restriction. Studies assessing the diagnostic accuracy of the TyG index against the hyperinsulinemic-euglycemic clamp (HIEC) or any other IR biochemical were assessed independently and in duplicate. Diagnostic accuracy measures (sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratios) were extracted independently and in duplicate. The QUADAS-2 tool was used to assess the risk of bias of independent studies. Results. We identified 15 eligible studies with 69,922 participants and an overall quality of low to moderate. The TyG index was evaluated by HIEC and HOMA as reference tests. The highest achieved sensitivity was 96% using HIEC, and the highest specificity was of 99% using HOMA-IR, with a cutoff value of 4.68. AUC values varied from 0.59 to 0.88. Cutoff values for IR were variable between studies, limiting its comparability. Conclusion. In this systematic review, we found moderate-to-low quality evidence about the usefulness of the TyG index as a surrogate biochemical marker of IR. Due to the lack of a standardized IR definition and heterogeneity between studies, further validation and standardized cutoff values are needed to be used in clinical practice. |
| format | Article |
| id | doaj-art-ef61e16f95a54992ab5578f87c2a2360 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ef61e16f95a54992ab5578f87c2a23602025-02-03T00:58:45ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/46785264678526Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic ReviewAdriana Sánchez-García0René Rodríguez-Gutiérrez1Leonardo Mancillas-Adame2Victoria González-Nava3Alejandro Díaz González-Colmenero4Ricardo Cesar Solis5Neri Alejandro Álvarez-Villalobos6José Gerardo González-González7Universidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Endocrinology Division, Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoUniversidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Endocrinology Division, Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoUniversidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Endocrinology Division, Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoUniversidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Endocrinology Division, Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoUniversidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Endocrinology Division, Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoUniversidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Endocrinology Division, Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoUniversidad Autonoma de Nuevo Leon, Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit México), Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoUniversidad Autonoma de Nuevo Leon, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Endocrinology Division, Av. Madero y Gonzalitos S/n, Mitras Centro, Monterrey 64460, Nuevo León, MexicoIntroduction. The triglyceride and glucose (TyG) index has been described as a biochemical marker of insulin resistance (IR); however, its diagnostic accuracy remains uncertain. Objective. To summarize the evidence assessing the diagnostic accuracy of the TyG index regarding IR. Methods. A comprehensive search in MEDLINE, EMBASE, Web of Science, and Scopus was performed without any language restriction. Studies assessing the diagnostic accuracy of the TyG index against the hyperinsulinemic-euglycemic clamp (HIEC) or any other IR biochemical were assessed independently and in duplicate. Diagnostic accuracy measures (sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratios) were extracted independently and in duplicate. The QUADAS-2 tool was used to assess the risk of bias of independent studies. Results. We identified 15 eligible studies with 69,922 participants and an overall quality of low to moderate. The TyG index was evaluated by HIEC and HOMA as reference tests. The highest achieved sensitivity was 96% using HIEC, and the highest specificity was of 99% using HOMA-IR, with a cutoff value of 4.68. AUC values varied from 0.59 to 0.88. Cutoff values for IR were variable between studies, limiting its comparability. Conclusion. In this systematic review, we found moderate-to-low quality evidence about the usefulness of the TyG index as a surrogate biochemical marker of IR. Due to the lack of a standardized IR definition and heterogeneity between studies, further validation and standardized cutoff values are needed to be used in clinical practice.http://dx.doi.org/10.1155/2020/4678526 |
| spellingShingle | Adriana Sánchez-García René Rodríguez-Gutiérrez Leonardo Mancillas-Adame Victoria González-Nava Alejandro Díaz González-Colmenero Ricardo Cesar Solis Neri Alejandro Álvarez-Villalobos José Gerardo González-González Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review International Journal of Endocrinology |
| title | Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review |
| title_full | Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review |
| title_fullStr | Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review |
| title_full_unstemmed | Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review |
| title_short | Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review |
| title_sort | diagnostic accuracy of the triglyceride and glucose index for insulin resistance a systematic review |
| url | http://dx.doi.org/10.1155/2020/4678526 |
| work_keys_str_mv | AT adrianasanchezgarcia diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview AT renerodriguezgutierrez diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview AT leonardomancillasadame diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview AT victoriagonzaleznava diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview AT alejandrodiazgonzalezcolmenero diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview AT ricardocesarsolis diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview AT nerialejandroalvarezvillalobos diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview AT josegerardogonzalezgonzalez diagnosticaccuracyofthetriglycerideandglucoseindexforinsulinresistanceasystematicreview |