Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i>
Cyclic nucleotide signaling pathways play essential roles in the physiology of the nematode <i>Caenorhabditis elegans</i>, influencing processes such as reproduction, environmental sensing, and cellular homeostasis. The intracellular levels of cAMP and cGMP are tightly regulated by their...
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MDPI AG
2025-07-01
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| author | Kranti K. Galande Rick H. Cote |
| author_facet | Kranti K. Galande Rick H. Cote |
| author_sort | Kranti K. Galande |
| collection | DOAJ |
| description | Cyclic nucleotide signaling pathways play essential roles in the physiology of the nematode <i>Caenorhabditis elegans</i>, influencing processes such as reproduction, environmental sensing, and cellular homeostasis. The intracellular levels of cAMP and cGMP are tightly regulated by their synthesis by adenylyl and guanylyl cyclases and their degradation catalyzed by 3′,5′-cyclic nucleotide phosphodiesterases (PDEs). Mammals possess eleven PDE families (PDE1 through PDE11), whereas nematode genomes contain six PDE genes orthologous to six of the mammalian PDE families. Despite their evolutionary conservation, the signaling pathways, regulatory mechanisms, and enzymatic properties of nematode PDEs remain incompletely understood. This review synthesizes current knowledge on the regulation of cyclic nucleotide levels in <i>C. elegans</i>, highlighting how dysregulation of nematode PDEs affects a wide range of physiological and behavioral processes, including sensory transduction, development, and locomotion. |
| format | Article |
| id | doaj-art-ef5f22e8cf9b48a2bca41530e132c60c |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj-art-ef5f22e8cf9b48a2bca41530e132c60c2025-08-20T03:02:48ZengMDPI AGCells2073-44092025-07-011415117410.3390/cells14151174Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i>Kranti K. Galande0Rick H. Cote1Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USADepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USACyclic nucleotide signaling pathways play essential roles in the physiology of the nematode <i>Caenorhabditis elegans</i>, influencing processes such as reproduction, environmental sensing, and cellular homeostasis. The intracellular levels of cAMP and cGMP are tightly regulated by their synthesis by adenylyl and guanylyl cyclases and their degradation catalyzed by 3′,5′-cyclic nucleotide phosphodiesterases (PDEs). Mammals possess eleven PDE families (PDE1 through PDE11), whereas nematode genomes contain six PDE genes orthologous to six of the mammalian PDE families. Despite their evolutionary conservation, the signaling pathways, regulatory mechanisms, and enzymatic properties of nematode PDEs remain incompletely understood. This review synthesizes current knowledge on the regulation of cyclic nucleotide levels in <i>C. elegans</i>, highlighting how dysregulation of nematode PDEs affects a wide range of physiological and behavioral processes, including sensory transduction, development, and locomotion.https://www.mdpi.com/2073-4409/14/15/1174cyclic nucleotide signaling pathwayscAMPcGMPcyclic nucleotide phosphodiesterase<i>C. elegans</i>nematode |
| spellingShingle | Kranti K. Galande Rick H. Cote Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i> Cells cyclic nucleotide signaling pathways cAMP cGMP cyclic nucleotide phosphodiesterase <i>C. elegans</i> nematode |
| title | Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i> |
| title_full | Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i> |
| title_fullStr | Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i> |
| title_short | Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode <i>Caenorhabditis elegans</i> |
| title_sort | roles of cyclic nucleotide phosphodiesterases in signal transduction pathways in the nematode i caenorhabditis elegans i |
| topic | cyclic nucleotide signaling pathways cAMP cGMP cyclic nucleotide phosphodiesterase <i>C. elegans</i> nematode |
| url | https://www.mdpi.com/2073-4409/14/15/1174 |
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