Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort
Background. There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. We aimed to determine w...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/5439539 |
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| author | Doron Boltin Zohar Levi Tsachi Tsadok Perets Hemda Schmilovitz-Weiss Rachel Gingold-Belfer Ram Dickman Iris Dotan |
| author_facet | Doron Boltin Zohar Levi Tsachi Tsadok Perets Hemda Schmilovitz-Weiss Rachel Gingold-Belfer Ram Dickman Iris Dotan |
| author_sort | Doron Boltin |
| collection | DOAJ |
| description | Background. There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. We aimed to determine whether the magnitude of C13-UBT result is related to treatment success. Methods. Adult patients who underwent a first-time 13C-urea breath test between January 2010 and January 2016 were included. In order to isolate a naïve test-and-treat population who were unlikely to have undergone an initial endoscopy-based H. pylori test, we excluded patients > 45 years and those with a previous C13-UBT. Data were extracted from the Clalit Health Services laboratory database. Results. A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included. C13-UBT was positive in 48,509 (51.3%) subjects. A confirmatory posttreatment C13-UBT was performed in 18,375 (37.8%), and eradication was successful in 12,018 (65.4%). The mean C13-UBT recording was 20.6 ± 16.2 DOB in subjects with successful eradication and 19.5 ± 13.1 DOB in subjects with treatment failure (OR, 1.01; 95% CI 1.00-1.01, p<0.01). Among patients in the upper quintile of C13-UBT measurement, eradication was achieved in 67.6%, compared to 62.6% in the lower quintile (OR, 1.22; 95% CI 1.11-1.35, p<0.01). Subjects in the top 1 percentile (C13-UBT ≥ 70 DOB) achieved eradication in 75.0%, compared to 65.3% among subjects with C13-UBT < 70 DOB (OR, 1.59; 95% CI 1.05-2.41, p<0.01). Conclusions. The superiority in H. pylori eradication observed in subjects with a higher C13-UBT DOB is small but significant. Further studies should examine the physiological and microbiological basis for this finding. |
| format | Article |
| id | doaj-art-ef5ee3c03e134057b69606f3fbbe8643 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ef5ee3c03e134057b69606f3fbbe86432025-02-03T05:52:14ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/54395395439539Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based CohortDoron Boltin0Zohar Levi1Tsachi Tsadok Perets2Hemda Schmilovitz-Weiss3Rachel Gingold-Belfer4Ram Dickman5Iris Dotan6Division of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, IsraelDivision of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, IsraelGastroenterology Laboratory, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, IsraelDivision of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, IsraelDivision of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, IsraelDivision of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, IsraelDivision of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, IsraelBackground. There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. We aimed to determine whether the magnitude of C13-UBT result is related to treatment success. Methods. Adult patients who underwent a first-time 13C-urea breath test between January 2010 and January 2016 were included. In order to isolate a naïve test-and-treat population who were unlikely to have undergone an initial endoscopy-based H. pylori test, we excluded patients > 45 years and those with a previous C13-UBT. Data were extracted from the Clalit Health Services laboratory database. Results. A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included. C13-UBT was positive in 48,509 (51.3%) subjects. A confirmatory posttreatment C13-UBT was performed in 18,375 (37.8%), and eradication was successful in 12,018 (65.4%). The mean C13-UBT recording was 20.6 ± 16.2 DOB in subjects with successful eradication and 19.5 ± 13.1 DOB in subjects with treatment failure (OR, 1.01; 95% CI 1.00-1.01, p<0.01). Among patients in the upper quintile of C13-UBT measurement, eradication was achieved in 67.6%, compared to 62.6% in the lower quintile (OR, 1.22; 95% CI 1.11-1.35, p<0.01). Subjects in the top 1 percentile (C13-UBT ≥ 70 DOB) achieved eradication in 75.0%, compared to 65.3% among subjects with C13-UBT < 70 DOB (OR, 1.59; 95% CI 1.05-2.41, p<0.01). Conclusions. The superiority in H. pylori eradication observed in subjects with a higher C13-UBT DOB is small but significant. Further studies should examine the physiological and microbiological basis for this finding.http://dx.doi.org/10.1155/2018/5439539 |
| spellingShingle | Doron Boltin Zohar Levi Tsachi Tsadok Perets Hemda Schmilovitz-Weiss Rachel Gingold-Belfer Ram Dickman Iris Dotan Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort Gastroenterology Research and Practice |
| title | Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort |
| title_full | Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort |
| title_fullStr | Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort |
| title_full_unstemmed | Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort |
| title_short | Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort |
| title_sort | correlation between quantitative 13c urea breath test and helicobacter pylori treatment success in a population based cohort |
| url | http://dx.doi.org/10.1155/2018/5439539 |
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