Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution.

Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution.

Only a few genes remain in the mitochondrial genome retained by every eukaryotic organism that carry out essential functions and are implicated in severe diseases. Experimentally relocating these few genes to the nucleus therefore has both therapeutic and evolutionary implications. Numerous unproduc...

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Main Authors: Maïlis Bietenhader, Alexandre Martos, Emmanuel Tetaud, Raeka S Aiyar, Carole H Sellem, Roza Kucharczyk, Sandra Clauder-Münster, Marie-France Giraud, François Godard, Bénédicte Salin, Isabelle Sagot, Julien Gagneur, Michelle Déquard-Chablat, Véronique Contamine, Sylvie Hermann-Le Denmat, Annie Sainsard-Chanet, Lars M Steinmetz, Jean-Paul di Rago
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002876&type=printable
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