Engineered endoplasmic reticulum-targeting nanodrugs with Piezo1 inhibition and promotion of cell uptake for subarachnoid hemorrhage inflammation repair

Engineered endoplasmic reticulum-targeting nanodrugs with Piezo1 inhibition and promotion of cell uptake for subarachnoid hemorrhage inflammation repair

Abstract Subarachnoid hemorrhage (SAH) is a life-threatening acute hemorrhagic cerebrovascular condition, often presenting with severe headaches caused by intracranial hypertension, which in severe cases can lead to brain herniation. Piezo1 is a mechanosensitive ion channel protein whose mechanical...

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Bibliographic Details
Main Authors: Xiaojian Zhang, Enyan Jiang, Wangyang Fu, Yuanyuan Wang, Yiping Wang, Zhen Fang, Zichen Zhang, Jiajia Duan, Jia Zeng, Yang Yan, Fei Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Piezo1
Engineered endoplasmic reticulum
Intracranial hypertension
Subarachnoid hemorrhage
Online Access:https://doi.org/10.1186/s12951-025-03305-1
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