Multipotent mesenchymal stem cells in renal transplantation
Kidney transplantation is the most effective treatment for the end-stage chronic renal disease that has been observed to increase in the incidence consistently in recent years. Despite the achievements in immunosuppressive therapy in patients after renal transplantation, the graft survival length ha...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2019-03-01
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| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/419 |
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| author | N. V. Borovkova M. Sh. Khubutiya O. N. Rzhevskaya A. V. Pinchuk D. A. Vasil’chenkov |
| author_facet | N. V. Borovkova M. Sh. Khubutiya O. N. Rzhevskaya A. V. Pinchuk D. A. Vasil’chenkov |
| author_sort | N. V. Borovkova |
| collection | DOAJ |
| description | Kidney transplantation is the most effective treatment for the end-stage chronic renal disease that has been observed to increase in the incidence consistently in recent years. Despite the achievements in immunosuppressive therapy in patients after renal transplantation, the graft survival length has remained unchangeable during the recent few decades. Bone marrow multipotent mesenchymal (stromal) stem cells (BM MMSCs) are known as a potential tool to influence this situation. Since their discovery in the middle of the XX century, their wide therapeutic potential in the transplantation of solid organs was demonstrated both in experimental and clinical trials. They have the ability to modify recipient’s immune response and improve postoperative course, however, having a low level of their own immunogenicity. MMSCs realize their properties through interactions both with the innate and adoptive immune system. Meanwhile, actual questions such as an optimal dosage and injection timing are still need answers. Actual experience of both experimental and clinical use of MMSCs in kidney transplantation has been analyzed in the present publication. |
| format | Article |
| id | doaj-art-ef56c6e6c2554b3ea8ca2807dd266afa |
| institution | Kabale University |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-ef56c6e6c2554b3ea8ca2807dd266afa2025-08-20T03:56:36ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092019-03-01111213610.23873/2074-0506-2019-11-1-21-36398Multipotent mesenchymal stem cells in renal transplantationN. V. Borovkova0M. Sh. Khubutiya1O. N. Rzhevskaya2A. V. Pinchuk3D. A. Vasil’chenkov4N.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineA.I. Yevdokimov Moscow State University of Medicine and DentistryKidney transplantation is the most effective treatment for the end-stage chronic renal disease that has been observed to increase in the incidence consistently in recent years. Despite the achievements in immunosuppressive therapy in patients after renal transplantation, the graft survival length has remained unchangeable during the recent few decades. Bone marrow multipotent mesenchymal (stromal) stem cells (BM MMSCs) are known as a potential tool to influence this situation. Since their discovery in the middle of the XX century, their wide therapeutic potential in the transplantation of solid organs was demonstrated both in experimental and clinical trials. They have the ability to modify recipient’s immune response and improve postoperative course, however, having a low level of their own immunogenicity. MMSCs realize their properties through interactions both with the innate and adoptive immune system. Meanwhile, actual questions such as an optimal dosage and injection timing are still need answers. Actual experience of both experimental and clinical use of MMSCs in kidney transplantation has been analyzed in the present publication.https://www.jtransplantologiya.ru/jour/article/view/419bone marrow multipotent mesenchymal stem cellsrenal transplantationtoleranceimmunosuppressionrecipientrejectionimmune responseinflammationregenerationimmunogenicity |
| spellingShingle | N. V. Borovkova M. Sh. Khubutiya O. N. Rzhevskaya A. V. Pinchuk D. A. Vasil’chenkov Multipotent mesenchymal stem cells in renal transplantation Трансплантология (Москва) bone marrow multipotent mesenchymal stem cells renal transplantation tolerance immunosuppression recipient rejection immune response inflammation regeneration immunogenicity |
| title | Multipotent mesenchymal stem cells in renal transplantation |
| title_full | Multipotent mesenchymal stem cells in renal transplantation |
| title_fullStr | Multipotent mesenchymal stem cells in renal transplantation |
| title_full_unstemmed | Multipotent mesenchymal stem cells in renal transplantation |
| title_short | Multipotent mesenchymal stem cells in renal transplantation |
| title_sort | multipotent mesenchymal stem cells in renal transplantation |
| topic | bone marrow multipotent mesenchymal stem cells renal transplantation tolerance immunosuppression recipient rejection immune response inflammation regeneration immunogenicity |
| url | https://www.jtransplantologiya.ru/jour/article/view/419 |
| work_keys_str_mv | AT nvborovkova multipotentmesenchymalstemcellsinrenaltransplantation AT mshkhubutiya multipotentmesenchymalstemcellsinrenaltransplantation AT onrzhevskaya multipotentmesenchymalstemcellsinrenaltransplantation AT avpinchuk multipotentmesenchymalstemcellsinrenaltransplantation AT davasilchenkov multipotentmesenchymalstemcellsinrenaltransplantation |