Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort Study
Abstract BackgroundPatients with stroke have high rates of all-cause readmission and case fatality. Limited information is available on how to predict these outcomes. ObjectiveWe aimed to assess whether adding the initial National Institutes of Health Stroke Scale...
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JMIR Publications
2025-05-01
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| Series: | JMIR Medical Informatics |
| Online Access: | https://medinform.jmir.org/2025/1/e69102 |
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| author | Mai N Nguyen-Huynh Janet Alexander Zheng Zhu Melissa Meighan Gabriel Escobar |
| author_facet | Mai N Nguyen-Huynh Janet Alexander Zheng Zhu Melissa Meighan Gabriel Escobar |
| author_sort | Mai N Nguyen-Huynh |
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Abstract
BackgroundPatients with stroke have high rates of all-cause readmission and case fatality. Limited information is available on how to predict these outcomes.
ObjectiveWe aimed to assess whether adding the initial National Institutes of Health Stroke Scale (NIHSS) score or modified Rankin scale (mRS) score at discharge improved predictive models of 30-day nonelective readmission or 30-day mortality poststroke.
MethodsUsing a cohort of patients with ischemic stroke in a large multiethnic integrated health care system from June 15, 2018, to April 29, 2020, we tested 2 predictive models for a composite outcome (30-day nonelective readmission or death). The models were based on administrative data (Length of Stay, Acuity, Charlson Comorbidities, Emergency Department Use score; LACE) as well as a comprehensive model (Transition Support Level; TSL). The models, initial NIHSS score, and mRS scores at discharge, were tested independently and in combination with age and sex. We assessed model performance using the area under the receiver operator characteristic (c-statistic), Nagelkerke pseudo-R2
ResultsThe study cohort included 4843 patients with 5014 stroke hospitalizations. Average age was 71.9 (SD 14) years, 50.6% (2537/5014) were female, and 52.1% (2614/5014) were White. Median initial NIHSS score was 4 (IQR 2-8). There were 538 (10.7%) nonelective readmissions and 150 (3.9%) deaths within 30 days. The logistic models revealed that the best performing models were TSL (c-statistic=0.69) and TSL plus mRS score at discharge (c-statistic=0.69).
ConclusionsWe found that neither the initial NIHSS score nor the mRS score at discharge significantly enhanced the predictive ability of the LACE or TSL models. Future efforts at prediction of short-term stroke outcomes will need to incorporate new data elements. |
| format | Article |
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| institution | OA Journals |
| issn | 2291-9694 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | JMIR Publications |
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| series | JMIR Medical Informatics |
| spelling | doaj-art-ef54d49d1ec24c90ba1858a8f337c07d2025-08-20T01:51:00ZengJMIR PublicationsJMIR Medical Informatics2291-96942025-05-0113e69102e6910210.2196/69102Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort StudyMai N Nguyen-Huynhhttp://orcid.org/0000-0002-8228-0282Janet Alexanderhttp://orcid.org/0000-0002-2566-8707Zheng Zhuhttp://orcid.org/0009-0001-1357-6637Melissa Meighanhttp://orcid.org/0000-0001-5107-3398Gabriel Escobarhttp://orcid.org/0000-0003-2540-3327 Abstract BackgroundPatients with stroke have high rates of all-cause readmission and case fatality. Limited information is available on how to predict these outcomes. ObjectiveWe aimed to assess whether adding the initial National Institutes of Health Stroke Scale (NIHSS) score or modified Rankin scale (mRS) score at discharge improved predictive models of 30-day nonelective readmission or 30-day mortality poststroke. MethodsUsing a cohort of patients with ischemic stroke in a large multiethnic integrated health care system from June 15, 2018, to April 29, 2020, we tested 2 predictive models for a composite outcome (30-day nonelective readmission or death). The models were based on administrative data (Length of Stay, Acuity, Charlson Comorbidities, Emergency Department Use score; LACE) as well as a comprehensive model (Transition Support Level; TSL). The models, initial NIHSS score, and mRS scores at discharge, were tested independently and in combination with age and sex. We assessed model performance using the area under the receiver operator characteristic (c-statistic), Nagelkerke pseudo-R2 ResultsThe study cohort included 4843 patients with 5014 stroke hospitalizations. Average age was 71.9 (SD 14) years, 50.6% (2537/5014) were female, and 52.1% (2614/5014) were White. Median initial NIHSS score was 4 (IQR 2-8). There were 538 (10.7%) nonelective readmissions and 150 (3.9%) deaths within 30 days. The logistic models revealed that the best performing models were TSL (c-statistic=0.69) and TSL plus mRS score at discharge (c-statistic=0.69). ConclusionsWe found that neither the initial NIHSS score nor the mRS score at discharge significantly enhanced the predictive ability of the LACE or TSL models. Future efforts at prediction of short-term stroke outcomes will need to incorporate new data elements.https://medinform.jmir.org/2025/1/e69102 |
| spellingShingle | Mai N Nguyen-Huynh Janet Alexander Zheng Zhu Melissa Meighan Gabriel Escobar Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort Study JMIR Medical Informatics |
| title | Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort Study |
| title_full | Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort Study |
| title_fullStr | Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort Study |
| title_full_unstemmed | Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort Study |
| title_short | Effects of the National Institutes of Health Stroke Scale and Modified Rankin Scale on Predictive Models of 30-Day Nonelective Readmission and Mortality After Ischemic Stroke: Cohort Study |
| title_sort | effects of the national institutes of health stroke scale and modified rankin scale on predictive models of 30 day nonelective readmission and mortality after ischemic stroke cohort study |
| url | https://medinform.jmir.org/2025/1/e69102 |
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