Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug Delivery
Measurements of dynamic surface tension were carried out in aqueous systems (water or 0.1 mM Triton X-100) comprising nanoparticles formed from chemically modified polyaldehyde dextran (PAD). The nanostructures, considered as potential drug carriers in aerosol therapy, were obtained from biocompatib...
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Polish Academy of Sciences Committee of Chemical and Process Engineering
2017-03-01
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| Series: | Chemical and Process Engineering |
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| author | Jabłczyńska Katarzyna Sosnowski Tomasz R. |
| author_facet | Jabłczyńska Katarzyna Sosnowski Tomasz R. |
| author_sort | Jabłczyńska Katarzyna |
| collection | DOAJ |
| description | Measurements of dynamic surface tension were carried out in aqueous systems (water or 0.1 mM Triton X-100) comprising nanoparticles formed from chemically modified polyaldehyde dextran (PAD). The nanostructures, considered as potential drug carriers in aerosol therapy, were obtained from biocompatible polysaccharides by successive oxidation and reactive coiling in an aqueous solution. The dynamic surface tension of the samples was determined by the maximum bubble pressure (MBP) method and by the axisymmetric drop shape analysis (ADSA). Experiments with harmonic area perturbations were also carried out in order to determine surface dilatational viscoelasticity. PAD showed a remarkable surface activity. Ward-Tordai equation was used to determine the equilibrium surface tension and diffusion coefficient of PAD nanoparticles (D = 2.3×10-6 m2/s). In a mixture with Triton X-100, PAD particles showed co-adsorption and synergic effect in surface tension reduction at short times (below 10 s). Tested nanoparticles had impact on surface rheology in a mixed system with nonionic surfactant, suggesting their possible interactions with the lung surfactant system after inhalation. This preliminary investigation sets the methodological approach for further research related to the influence of inhaled PAD nanoparticles on the lung surfactant and mass transfer processes in the respiratory system. |
| format | Article |
| id | doaj-art-ef542d25079a403883be2bc255b6dbb7 |
| institution | OA Journals |
| issn | 2300-1925 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Polish Academy of Sciences Committee of Chemical and Process Engineering |
| record_format | Article |
| series | Chemical and Process Engineering |
| spelling | doaj-art-ef542d25079a403883be2bc255b6dbb72025-08-20T02:13:36ZengPolish Academy of Sciences Committee of Chemical and Process EngineeringChemical and Process Engineering2300-19252017-03-01381677710.1515/cpe-2017-0006cpe-2017-0006Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug DeliveryJabłczyńska Katarzyna0Sosnowski Tomasz R.1Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, PolandWarsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, PolandMeasurements of dynamic surface tension were carried out in aqueous systems (water or 0.1 mM Triton X-100) comprising nanoparticles formed from chemically modified polyaldehyde dextran (PAD). The nanostructures, considered as potential drug carriers in aerosol therapy, were obtained from biocompatible polysaccharides by successive oxidation and reactive coiling in an aqueous solution. The dynamic surface tension of the samples was determined by the maximum bubble pressure (MBP) method and by the axisymmetric drop shape analysis (ADSA). Experiments with harmonic area perturbations were also carried out in order to determine surface dilatational viscoelasticity. PAD showed a remarkable surface activity. Ward-Tordai equation was used to determine the equilibrium surface tension and diffusion coefficient of PAD nanoparticles (D = 2.3×10-6 m2/s). In a mixture with Triton X-100, PAD particles showed co-adsorption and synergic effect in surface tension reduction at short times (below 10 s). Tested nanoparticles had impact on surface rheology in a mixed system with nonionic surfactant, suggesting their possible interactions with the lung surfactant system after inhalation. This preliminary investigation sets the methodological approach for further research related to the influence of inhaled PAD nanoparticles on the lung surfactant and mass transfer processes in the respiratory system.http://www.degruyter.com/view/j/cpe.2017.38.issue-1/cpe-2017-0006/cpe-2017-0006.xml?format=INTpolysaccharide nanoparticleslung surfactantdynamic surface tensionsurface viscoelasticityhysteresis |
| spellingShingle | Jabłczyńska Katarzyna Sosnowski Tomasz R. Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug Delivery Chemical and Process Engineering polysaccharide nanoparticles lung surfactant dynamic surface tension surface viscoelasticity hysteresis |
| title | Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug Delivery |
| title_full | Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug Delivery |
| title_fullStr | Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug Delivery |
| title_full_unstemmed | Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug Delivery |
| title_short | Adsorption and Co-Adsorption of Polyaldehyde Dextran Nanoparticles and Nonionic Surfactant at an Air–Water Interface: Potential Implications for Pulmonary Drug Delivery |
| title_sort | adsorption and co adsorption of polyaldehyde dextran nanoparticles and nonionic surfactant at an air water interface potential implications for pulmonary drug delivery |
| topic | polysaccharide nanoparticles lung surfactant dynamic surface tension surface viscoelasticity hysteresis |
| url | http://www.degruyter.com/view/j/cpe.2017.38.issue-1/cpe-2017-0006/cpe-2017-0006.xml?format=INT |
| work_keys_str_mv | AT jabłczynskakatarzyna adsorptionandcoadsorptionofpolyaldehydedextrannanoparticlesandnonionicsurfactantatanairwaterinterfacepotentialimplicationsforpulmonarydrugdelivery AT sosnowskitomaszr adsorptionandcoadsorptionofpolyaldehydedextrannanoparticlesandnonionicsurfactantatanairwaterinterfacepotentialimplicationsforpulmonarydrugdelivery |