THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE
Abstract. Functional activity of thymus in normal donors and patients with various clinical forms of bronchial asthma was evaluated by means of assessing TREC-positive T-cell numbers. In spite of well-known alterations in parameters of T-cell homeostasis, TREC levels in CD4+and CD8+ lymphocytes from...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/325 |
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| author | E. A. Blinova V. M. Nepomniashchikh V. S. Kozhevnikov |
| author_facet | E. A. Blinova V. M. Nepomniashchikh V. S. Kozhevnikov |
| author_sort | E. A. Blinova |
| collection | DOAJ |
| description | Abstract. Functional activity of thymus in normal donors and patients with various clinical forms of bronchial asthma was evaluated by means of assessing TREC-positive T-cell numbers. In spite of well-known alterations in parameters of T-cell homeostasis, TREC levels in CD4+and CD8+ lymphocytes from the patients with asthma did not differ significantly from those in donors. There were also no significant differences in TREC-containing cell numbers, dependent on clinical types of bronchial asthma and IgE levels. However, the patients with a recent disease onset (duration of several days to one year) showed increased TREC positivity in CD4+ and CD8+ lymphocytes, as compared with donors and those patients who underwent basal therapy with glucocorticoids, and during long-term disorder (> 1 year). Enhanced thymopoiesis at initial stages of the disease may be associated with thymic stromal lymphopoietin which contributes to development of bronchial asthma, and normally participates in the process of T cell production. |
| format | Article |
| id | doaj-art-ef49a02cc1f643f39008c60d41c7e2dc |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-ef49a02cc1f643f39008c60d41c7e2dc2025-08-20T03:44:08ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01141-216316810.15789/1563-0625-2012-1-2-163-168322THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASEE. A. Blinova0V. M. Nepomniashchikh1V. S. Kozhevnikov2НИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскНИИ клинической иммунологии СО РАМН, г. НовосибирскAbstract. Functional activity of thymus in normal donors and patients with various clinical forms of bronchial asthma was evaluated by means of assessing TREC-positive T-cell numbers. In spite of well-known alterations in parameters of T-cell homeostasis, TREC levels in CD4+and CD8+ lymphocytes from the patients with asthma did not differ significantly from those in donors. There were also no significant differences in TREC-containing cell numbers, dependent on clinical types of bronchial asthma and IgE levels. However, the patients with a recent disease onset (duration of several days to one year) showed increased TREC positivity in CD4+ and CD8+ lymphocytes, as compared with donors and those patients who underwent basal therapy with glucocorticoids, and during long-term disorder (> 1 year). Enhanced thymopoiesis at initial stages of the disease may be associated with thymic stromal lymphopoietin which contributes to development of bronchial asthma, and normally participates in the process of T cell production.https://www.mimmun.ru/mimmun/article/view/325thymopoiesistrect lymphocytesbronchial asthma |
| spellingShingle | E. A. Blinova V. M. Nepomniashchikh V. S. Kozhevnikov THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE Медицинская иммунология thymopoiesis trec t lymphocytes bronchial asthma |
| title | THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE |
| title_full | THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE |
| title_fullStr | THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE |
| title_full_unstemmed | THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE |
| title_short | THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE |
| title_sort | thymopoiesis intensity in patients with bronchial asthma depending on duration of the disease |
| topic | thymopoiesis trec t lymphocytes bronchial asthma |
| url | https://www.mimmun.ru/mimmun/article/view/325 |
| work_keys_str_mv | AT eablinova thymopoiesisintensityinpatientswithbronchialasthmadependingondurationofthedisease AT vmnepomniashchikh thymopoiesisintensityinpatientswithbronchialasthmadependingondurationofthedisease AT vskozhevnikov thymopoiesisintensityinpatientswithbronchialasthmadependingondurationofthedisease |