The role of circRNAs in resistance to doxorubicin
Abstract Doxorubicin is an anthracyline recognized as an antitumor antibiotic agent. It is widely used in the chemotherapeutic regimens in different types of cancers. Resistance to doxorubicin is a major clinical obstacle and main cause of failure in cancer chemotherapy. Among different mechanisms i...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-11-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-024-01952-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850107421193666560 |
|---|---|
| author | Mahla Sanati Soudeh Ghafouri-Fard |
| author_facet | Mahla Sanati Soudeh Ghafouri-Fard |
| author_sort | Mahla Sanati |
| collection | DOAJ |
| description | Abstract Doxorubicin is an anthracyline recognized as an antitumor antibiotic agent. It is widely used in the chemotherapeutic regimens in different types of cancers. Resistance to doxorubicin is a major clinical obstacle and main cause of failure in cancer chemotherapy. Among different mechanisms involved in this process, the role of epigenetic factors has been highlighted. Circular RNAs (circRNAs) have a prominent role in this process. Here, we summarize the recent findings on the role of circRNAs in doxorubicin resistance, particularly in breast cancer and osteosarcoma and underscore their clinical application as potential biomarkers and therapeutic targets in this field. Recognition of the underlying mechanism of circRNAs involvement in doxorubicin resistance will expand our understanding of chemoresistance establishment and may provide a prospect to develop circRNA-based predictive biomarkers of chemotherapy or therapeutic strategies for cancer patients. |
| format | Article |
| id | doaj-art-ef475227befa48a7af0b77ccb4fe8794 |
| institution | OA Journals |
| issn | 1478-811X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-ef475227befa48a7af0b77ccb4fe87942025-08-20T02:38:35ZengBMCCell Communication and Signaling1478-811X2024-11-0122112010.1186/s12964-024-01952-9The role of circRNAs in resistance to doxorubicinMahla Sanati0Soudeh Ghafouri-Fard1Department of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesAbstract Doxorubicin is an anthracyline recognized as an antitumor antibiotic agent. It is widely used in the chemotherapeutic regimens in different types of cancers. Resistance to doxorubicin is a major clinical obstacle and main cause of failure in cancer chemotherapy. Among different mechanisms involved in this process, the role of epigenetic factors has been highlighted. Circular RNAs (circRNAs) have a prominent role in this process. Here, we summarize the recent findings on the role of circRNAs in doxorubicin resistance, particularly in breast cancer and osteosarcoma and underscore their clinical application as potential biomarkers and therapeutic targets in this field. Recognition of the underlying mechanism of circRNAs involvement in doxorubicin resistance will expand our understanding of chemoresistance establishment and may provide a prospect to develop circRNA-based predictive biomarkers of chemotherapy or therapeutic strategies for cancer patients.https://doi.org/10.1186/s12964-024-01952-9CircRNA; non-coding RNACancerDoxorubicin |
| spellingShingle | Mahla Sanati Soudeh Ghafouri-Fard The role of circRNAs in resistance to doxorubicin Cell Communication and Signaling CircRNA; non-coding RNA Cancer Doxorubicin |
| title | The role of circRNAs in resistance to doxorubicin |
| title_full | The role of circRNAs in resistance to doxorubicin |
| title_fullStr | The role of circRNAs in resistance to doxorubicin |
| title_full_unstemmed | The role of circRNAs in resistance to doxorubicin |
| title_short | The role of circRNAs in resistance to doxorubicin |
| title_sort | role of circrnas in resistance to doxorubicin |
| topic | CircRNA; non-coding RNA Cancer Doxorubicin |
| url | https://doi.org/10.1186/s12964-024-01952-9 |
| work_keys_str_mv | AT mahlasanati theroleofcircrnasinresistancetodoxorubicin AT soudehghafourifard theroleofcircrnasinresistancetodoxorubicin AT mahlasanati roleofcircrnasinresistancetodoxorubicin AT soudehghafourifard roleofcircrnasinresistancetodoxorubicin |