Computational design of diverse nuclear factor erythroid 2 activators with cellular antioxidative activity
Summary: Oxidative stress disrupts signaling pathways contributing to chronic diseases, while the KEAP1-NRF2 pathway is central to cellular antioxidant defenses. Current synthetic antioxidants struggle to activate this pathway efficiently or selectively. In this study, we employed deep learning algo...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422500882X |
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