Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy
Purpose: Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to in...
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Elsevier
2025-04-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000158 |
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| author | Shiyi Yin Jinyuan Wang Haihan Zhang Xuan Yang Jingting Luo Wenbin Wei |
| author_facet | Shiyi Yin Jinyuan Wang Haihan Zhang Xuan Yang Jingting Luo Wenbin Wei |
| author_sort | Shiyi Yin |
| collection | DOAJ |
| description | Purpose: Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function. Methods: This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed. Results: By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (P < 0.05), whereas differences between stages 2 and 3 were not statistically significant (P > 0.05). The FAZ area and perimeter showed no significant difference across the three stages (P > 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (P < 0.001). Multivariate regression analysis revealed that SVC-VD (P < 0.001), SVC-PA (P < 0.001) and choroid-PA (P = 0.030) were significantly associated with BCVA, while DVC-VD (P = 0.014), outer retinal thickness (P = 0.011), and CVI (P = 0.004) were significantly associated with visual field damage. Conclusions: SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy. |
| format | Article |
| id | doaj-art-ef3a69675d3448b99389d6600393946a |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-ef3a69675d3448b99389d6600393946a2025-02-04T04:10:21ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-04-0152104485Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophyShiyi Yin0Jinyuan Wang1Haihan Zhang2Xuan Yang3Jingting Luo4Wenbin Wei5Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Tsinghua Medicine, School of Clinical Medicine, Tsinghua University, Beijing 100084, China; Tsinghua Medicine, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua University, Beijing, ChinaBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Corresponding author.Purpose: Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function. Methods: This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed. Results: By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (P < 0.05), whereas differences between stages 2 and 3 were not statistically significant (P > 0.05). The FAZ area and perimeter showed no significant difference across the three stages (P > 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (P < 0.001). Multivariate regression analysis revealed that SVC-VD (P < 0.001), SVC-PA (P < 0.001) and choroid-PA (P = 0.030) were significantly associated with BCVA, while DVC-VD (P = 0.014), outer retinal thickness (P = 0.011), and CVI (P = 0.004) were significantly associated with visual field damage. Conclusions: SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy.http://www.sciencedirect.com/science/article/pii/S1572100025000158Bietti crystalline dystrophyOptical coherence tomography angiography (OCTA)Visual functionRetinochoroidal vasculaturePerfusion area |
| spellingShingle | Shiyi Yin Jinyuan Wang Haihan Zhang Xuan Yang Jingting Luo Wenbin Wei Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy Photodiagnosis and Photodynamic Therapy Bietti crystalline dystrophy Optical coherence tomography angiography (OCTA) Visual function Retinochoroidal vasculature Perfusion area |
| title | Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy |
| title_full | Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy |
| title_fullStr | Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy |
| title_full_unstemmed | Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy |
| title_short | Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy |
| title_sort | quantitative swept source optical coherence tomography angiography ss octa analysis of macular microvascular alterations in bietti crystalline dystrophy |
| topic | Bietti crystalline dystrophy Optical coherence tomography angiography (OCTA) Visual function Retinochoroidal vasculature Perfusion area |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000158 |
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