Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy
Introduction. Patients receiving chemotherapy for breast cancer may be at risk of developing cardiac dysfunction and electrophysiological abnormalities. The aim of this study is to evaluate alterations in electrocardiographic (ECG) parameters in breast cancer patients receiving chemotherapy. Materia...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/6678503 |
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| author | Xufei Liang Yueying Wang Xi Yin Xiaohong Gong Shuo Pan Ziliang Chen Xuhong Geng |
| author_facet | Xufei Liang Yueying Wang Xi Yin Xiaohong Gong Shuo Pan Ziliang Chen Xuhong Geng |
| author_sort | Xufei Liang |
| collection | DOAJ |
| description | Introduction. Patients receiving chemotherapy for breast cancer may be at risk of developing cardiac dysfunction and electrophysiological abnormalities. The aim of this study is to evaluate alterations in electrocardiographic (ECG) parameters in breast cancer patients receiving chemotherapy. Materials and Methods. This was a prospective single-center cohort study conducted in the Fourth Hospital of Hebei Medical University, China. Participants with breast cancer referred for chemotherapy from May 1, 2019, to October 1, 2019, were invited to participate in the study. Standard 12-lead ECG and echocardiography were performed at baseline or before chemotherapy (prechemotherapy) (T0), after 1 cycle (T1), after 3 cycles (T2), and at the end of chemotherapy (T3). Results. A total of 64 patients with diagnosed breast cancer undergoing chemotherapy were included. Echocardiographic parameters showed no significant variation during the entire procedure (all P>0.05). The incidence of abnormal ECG increased from 43.75% at baseline to 65.63% at the end of chemotherapy, of which only the prevalence of fragmented QRS (fQRS) was significantly increased after the drug regimen (26.56% to 53.13%). At the end of the treatment, heart rate, P-wave dispersion, corrected QT interval, T-peak to T-end, RR, SV1, RV5, Sokolow–Lyon index (SLI), and index of cardioelectrophysiological balance deteriorated markedly (all P<0.05). The area under the curve for SLI and QT dispersion (QTd) derived by ECG was 0.710 and 0.606, respectively. The cutoff value with 2.12 of SLI by ECG had a sensitivity of 67.2% and specificity of 71.9% for differentiating patients after therapy from baselines. The cutoff value with 0.55 of QTd had a sensitivity of 60.9% and specificity of 60.9%. Conclusions. The current study demonstrated that ECGs can be used to detect electrophysiological abnormalities in breast cancer patients receiving chemotherapy. ECG changes can reflect subclinical cardiac dysfunction before the echocardiographic abnormalities. |
| format | Article |
| id | doaj-art-ef35668b500547dca3591f2d71332f06 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-ef35668b500547dca3591f2d71332f062025-02-03T01:03:58ZengWileyCardiology Research and Practice2090-80162090-05972020-01-01202010.1155/2020/66785036678503Electrocardiographic Characteristics of Breast Cancer Patients Treated with ChemotherapyXufei Liang0Yueying Wang1Xi Yin2Xiaohong Gong3Shuo Pan4Ziliang Chen5Xuhong Geng6Department of Function, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaGraduate School of Medicine, Tianjin Medical University, Tianjin 300070, ChinaDepartment of Function, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Function, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaDepartment of Function, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaGraduate School of Medicine, Tianjin Medical University, Tianjin 300070, ChinaDepartment of Function, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaIntroduction. Patients receiving chemotherapy for breast cancer may be at risk of developing cardiac dysfunction and electrophysiological abnormalities. The aim of this study is to evaluate alterations in electrocardiographic (ECG) parameters in breast cancer patients receiving chemotherapy. Materials and Methods. This was a prospective single-center cohort study conducted in the Fourth Hospital of Hebei Medical University, China. Participants with breast cancer referred for chemotherapy from May 1, 2019, to October 1, 2019, were invited to participate in the study. Standard 12-lead ECG and echocardiography were performed at baseline or before chemotherapy (prechemotherapy) (T0), after 1 cycle (T1), after 3 cycles (T2), and at the end of chemotherapy (T3). Results. A total of 64 patients with diagnosed breast cancer undergoing chemotherapy were included. Echocardiographic parameters showed no significant variation during the entire procedure (all P>0.05). The incidence of abnormal ECG increased from 43.75% at baseline to 65.63% at the end of chemotherapy, of which only the prevalence of fragmented QRS (fQRS) was significantly increased after the drug regimen (26.56% to 53.13%). At the end of the treatment, heart rate, P-wave dispersion, corrected QT interval, T-peak to T-end, RR, SV1, RV5, Sokolow–Lyon index (SLI), and index of cardioelectrophysiological balance deteriorated markedly (all P<0.05). The area under the curve for SLI and QT dispersion (QTd) derived by ECG was 0.710 and 0.606, respectively. The cutoff value with 2.12 of SLI by ECG had a sensitivity of 67.2% and specificity of 71.9% for differentiating patients after therapy from baselines. The cutoff value with 0.55 of QTd had a sensitivity of 60.9% and specificity of 60.9%. Conclusions. The current study demonstrated that ECGs can be used to detect electrophysiological abnormalities in breast cancer patients receiving chemotherapy. ECG changes can reflect subclinical cardiac dysfunction before the echocardiographic abnormalities.http://dx.doi.org/10.1155/2020/6678503 |
| spellingShingle | Xufei Liang Yueying Wang Xi Yin Xiaohong Gong Shuo Pan Ziliang Chen Xuhong Geng Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy Cardiology Research and Practice |
| title | Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy |
| title_full | Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy |
| title_fullStr | Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy |
| title_full_unstemmed | Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy |
| title_short | Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy |
| title_sort | electrocardiographic characteristics of breast cancer patients treated with chemotherapy |
| url | http://dx.doi.org/10.1155/2020/6678503 |
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