Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development
Background. Poor placentation and systemic endothelial dysfunction have been identified as main events in Preeclampsia (PE). The relationship and chronology of these phenomena are important if we are to understand the pathophysiological mechanisms underlying this major clinical problem. Objectives....
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2012/909315 |
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| author | Augusto Henriques Fulgêncio Brandão Ludmila Maria Guimarães Pereira Alessandra Cristina de Oliveira Gonçalves Zilma Silveira Nogueira Reis Henrique Vítor Leite Antônio Carlos Vieira Cabral |
| author_facet | Augusto Henriques Fulgêncio Brandão Ludmila Maria Guimarães Pereira Alessandra Cristina de Oliveira Gonçalves Zilma Silveira Nogueira Reis Henrique Vítor Leite Antônio Carlos Vieira Cabral |
| author_sort | Augusto Henriques Fulgêncio Brandão |
| collection | DOAJ |
| description | Background. Poor placentation and systemic endothelial dysfunction have been identified as main events in Preeclampsia (PE). The relationship and chronology of these phenomena are important if we are to understand the pathophysiological mechanisms underlying this major clinical problem. Objectives. To compare the evolution of placentation and endothelial function in normotensive and preeclamptic pregnancies. Patients and methods. In a prospective cohort study, 59 pregnant women with a high risk of developing PE were subjected to flow-mediated dilation (FMD) and to Doppler velocimetry of uterine arteries in order to obtain their Pulsatility Index (UtA-PI). The variations in the FMD and UtA-PI values, between 16+0 and 19+6 and 24+0 and 27+6 weeks of gestation, were compared, taking PE development into consideration. Results. Nine patients developed PE and the other 50 women remained normotensive. At 16+0 to 19+6 weeks of pregnancy, patients that developed PE presented higher values of UtA-PI than the normotensive group, but there was no difference in FMD results between them. At 24+0 to 27+6 weeks, the patients that developed PE presented higher values of UtA-PI and lower values of FMD than the women that remained normotensive. Conclusions. These results corroborate the evidence that endothelial injury is secondary to poor placentation. |
| format | Article |
| id | doaj-art-ef3513830c8340db8aca4f1d9ca42d89 |
| institution | OA Journals |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-ef3513830c8340db8aca4f1d9ca42d892025-08-20T02:22:25ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/909315909315Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia DevelopmentAugusto Henriques Fulgêncio Brandão0Ludmila Maria Guimarães Pereira1Alessandra Cristina de Oliveira Gonçalves2Zilma Silveira Nogueira Reis3Henrique Vítor Leite4Antônio Carlos Vieira Cabral5Department of Obstetrics and Gynecology, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, BrazilFundação de Amparo à Pesquisa de Minas Gerais (Fapemig), 30130-100 Belo Horizonte, MG, BrazilFetal Medicine Center Hospital das Clínicas, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilFetal Medicine Center Hospital das Clínicas, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilFetal Medicine Center Hospital das Clínicas, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilFetal Medicine Center Hospital das Clínicas, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilBackground. Poor placentation and systemic endothelial dysfunction have been identified as main events in Preeclampsia (PE). The relationship and chronology of these phenomena are important if we are to understand the pathophysiological mechanisms underlying this major clinical problem. Objectives. To compare the evolution of placentation and endothelial function in normotensive and preeclamptic pregnancies. Patients and methods. In a prospective cohort study, 59 pregnant women with a high risk of developing PE were subjected to flow-mediated dilation (FMD) and to Doppler velocimetry of uterine arteries in order to obtain their Pulsatility Index (UtA-PI). The variations in the FMD and UtA-PI values, between 16+0 and 19+6 and 24+0 and 27+6 weeks of gestation, were compared, taking PE development into consideration. Results. Nine patients developed PE and the other 50 women remained normotensive. At 16+0 to 19+6 weeks of pregnancy, patients that developed PE presented higher values of UtA-PI than the normotensive group, but there was no difference in FMD results between them. At 24+0 to 27+6 weeks, the patients that developed PE presented higher values of UtA-PI and lower values of FMD than the women that remained normotensive. Conclusions. These results corroborate the evidence that endothelial injury is secondary to poor placentation.http://dx.doi.org/10.1155/2012/909315 |
| spellingShingle | Augusto Henriques Fulgêncio Brandão Ludmila Maria Guimarães Pereira Alessandra Cristina de Oliveira Gonçalves Zilma Silveira Nogueira Reis Henrique Vítor Leite Antônio Carlos Vieira Cabral Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development Journal of Pregnancy |
| title | Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development |
| title_full | Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development |
| title_fullStr | Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development |
| title_full_unstemmed | Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development |
| title_short | Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development |
| title_sort | comparative study of endothelial function and uterine artery doppler velocimetry between pregnant women with or without preeclampsia development |
| url | http://dx.doi.org/10.1155/2012/909315 |
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