Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2.

Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects a broader range of mammalian species than previously predicted, binding a diversity of angiotensin converting enzyme 2 (ACE2) orthologs despite extensive sequence divergence. Within this sequence degeneracy, we identify a rare sequ...

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Bibliographic Details
Main Authors: Gianni M Castiglione, Lingli Zhou, Zhenhua Xu, Zachary Neiman, Chien-Fu Hung, Elia J Duh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001510&type=printable
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