Compliance of extended infusion of piperacillin/tazobactam with the desired pharmacokinetic/pharmacodynamic index in septic patients

Compliance of extended infusion of piperacillin/tazobactam with the desired pharmacokinetic/pharmacodynamic index in septic patients

Background/Aim. Piperacillin (PIP)/tazobactam (TAZ) –PIP/TAZ is a beta-lactam antibiotic used to treat Gram-negative sepsis. The portion of the dosing interval during which antibiotic concentrations are above the minimal inhibitory concentration – MIC (fT>MIC) or, even more, four times higher tha...

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Bibliographic Details
Main Authors: Tomić Nataša, Vukmirović Saša, Sabo Stanislav, Uvelin Arsen, Popović Radmila, Vicković Sanja, Tomić Ljiljana, Tomić Zdenko
Format: Article
Language:English
Published: Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade 2025-01-01
Series:Vojnosanitetski Pregled
Subjects:
beta lactam
antibiotics
chromatography
high pressure liquid
drug resistance
microbial
infusion
intravenous
pharmacokinetics
pharmacology
sepsis
Online Access:https://doiserbia.nb.rs/img/doi/0042-8450/2025/0042-84502500029T.pdf
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