Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion
The sulfonylurea receptor 1 (SUR1) has been classified as a member of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter superfamily. SUR1, unlike the classic ABC transporters, assembles with Kir6.2, forming KATP channels to regulate the flux of potassium ions. In the central nervou...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2025.1536409/full |
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| author | Iván Alquisiras-Burgos Irlanda Peralta-Arrieta Mónica Espinoza-Rojo Alejandro Salazar-Salgado Iván Antonino-Olguín Iván Antonino-Olguín Alicia Sánchez-Mendoza María Sánchez-Aguilar Martha-Eugenia Ruiz-Tachiquín Hilda-Alicia Valdez-Salazar Alma Ortiz-Plata Javier Franco-Pérez Arturo Hernández-Cruz Penélope Aguilera |
| author_facet | Iván Alquisiras-Burgos Irlanda Peralta-Arrieta Mónica Espinoza-Rojo Alejandro Salazar-Salgado Iván Antonino-Olguín Iván Antonino-Olguín Alicia Sánchez-Mendoza María Sánchez-Aguilar Martha-Eugenia Ruiz-Tachiquín Hilda-Alicia Valdez-Salazar Alma Ortiz-Plata Javier Franco-Pérez Arturo Hernández-Cruz Penélope Aguilera |
| author_sort | Iván Alquisiras-Burgos |
| collection | DOAJ |
| description | The sulfonylurea receptor 1 (SUR1) has been classified as a member of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter superfamily. SUR1, unlike the classic ABC transporters, assembles with Kir6.2, forming KATP channels to regulate the flux of potassium ions. In the central nervous system, SUR1 is weakly expressed in some brain regions but is induced by pathological conditions in the different cell types of the neurovascular unit. Therefore, we first analyzed the expression of SUR1 in various rat tissues and brain regions to identify SUR1 isoforms and their mRNA exon composition under physiological conditions. Later, we focused on the SUR1 expression in the brain and heart after ischemia/reperfusion. We observed two SUR1 isoforms (170 and 60–75 kDa) abundantly expressed in most rat tissues, except for the testis and brain, where basal expression of these isoforms was relatively low and exhibit a band of 100 kDa. Every exons coding for the functional domains of SUR1 mRNA were amplified from the tissues and brain regions analyzed. Results from in vitro and in vivo experiments indicated that SUR1 isoforms previously identified (170 and 60–75 kDa) were dramatically overexpressed in the brain after middle cerebral artery occlusion followed by reperfusion. In contrast, myocardial infarction followed by reperfusion significantly reduced SUR1 isoform expression in the heart. This study demonstrates the expression of at least two SUR1 isoforms in various tissues and suggests that ischemic processes may differentially regulate SUR1 expression depending on the tissue injured. |
| format | Article |
| id | doaj-art-ef1d0897275c41f4b138485a533fe36b |
| institution | OA Journals |
| issn | 1662-5099 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj-art-ef1d0897275c41f4b138485a533fe36b2025-08-20T02:13:19ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992025-04-011810.3389/fnmol.2025.15364091536409Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusionIván Alquisiras-Burgos0Irlanda Peralta-Arrieta1Mónica Espinoza-Rojo2Alejandro Salazar-Salgado3Iván Antonino-Olguín4Iván Antonino-Olguín5Alicia Sánchez-Mendoza6María Sánchez-Aguilar7Martha-Eugenia Ruiz-Tachiquín8Hilda-Alicia Valdez-Salazar9Alma Ortiz-Plata10Javier Franco-Pérez11Arturo Hernández-Cruz12Penélope Aguilera13Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoLaboratorio de Transducción de Señales, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México, MexicoLaboratorio de Biología Molecular y Genómica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo de los Bravo, MexicoDepartamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, MexicoLaboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoLaboratorio de Biología Molecular y Genómica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo de los Bravo, MexicoDepartamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, MexicoDepartamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, MexicoUnidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoUnidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, MexicoLaboratorio de Patología Experimental, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoLaboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoDepartamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, MexicoLaboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoThe sulfonylurea receptor 1 (SUR1) has been classified as a member of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter superfamily. SUR1, unlike the classic ABC transporters, assembles with Kir6.2, forming KATP channels to regulate the flux of potassium ions. In the central nervous system, SUR1 is weakly expressed in some brain regions but is induced by pathological conditions in the different cell types of the neurovascular unit. Therefore, we first analyzed the expression of SUR1 in various rat tissues and brain regions to identify SUR1 isoforms and their mRNA exon composition under physiological conditions. Later, we focused on the SUR1 expression in the brain and heart after ischemia/reperfusion. We observed two SUR1 isoforms (170 and 60–75 kDa) abundantly expressed in most rat tissues, except for the testis and brain, where basal expression of these isoforms was relatively low and exhibit a band of 100 kDa. Every exons coding for the functional domains of SUR1 mRNA were amplified from the tissues and brain regions analyzed. Results from in vitro and in vivo experiments indicated that SUR1 isoforms previously identified (170 and 60–75 kDa) were dramatically overexpressed in the brain after middle cerebral artery occlusion followed by reperfusion. In contrast, myocardial infarction followed by reperfusion significantly reduced SUR1 isoform expression in the heart. This study demonstrates the expression of at least two SUR1 isoforms in various tissues and suggests that ischemic processes may differentially regulate SUR1 expression depending on the tissue injured.https://www.frontiersin.org/articles/10.3389/fnmol.2025.1536409/fullsulphonylurea 1 receptorSUR1brain ischemiaheart ischemiaAbcc8 |
| spellingShingle | Iván Alquisiras-Burgos Irlanda Peralta-Arrieta Mónica Espinoza-Rojo Alejandro Salazar-Salgado Iván Antonino-Olguín Iván Antonino-Olguín Alicia Sánchez-Mendoza María Sánchez-Aguilar Martha-Eugenia Ruiz-Tachiquín Hilda-Alicia Valdez-Salazar Alma Ortiz-Plata Javier Franco-Pérez Arturo Hernández-Cruz Penélope Aguilera Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion Frontiers in Molecular Neuroscience sulphonylurea 1 receptor SUR1 brain ischemia heart ischemia Abcc8 |
| title | Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion |
| title_full | Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion |
| title_fullStr | Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion |
| title_full_unstemmed | Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion |
| title_short | Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion |
| title_sort | expression of sur1 isoforms in the brain and heart after ischemia reperfusion |
| topic | sulphonylurea 1 receptor SUR1 brain ischemia heart ischemia Abcc8 |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2025.1536409/full |
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