Systematic Review and Meta-Analysis to Explore the Relationship of Increased Homocysteine, Lipid Levels and Lipid Ratios In-Cad
Background: Coronary artery disease (CAD) is a leading cause of morbidity and mortality globally, with elevated homocysteine levels increasingly recognized as an independent risk factor. This meta-analysis aims to evaluate the relationship between homocysteine levels and CAD risk by pooling data fro...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1961_24 |
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| Summary: | Background:
Coronary artery disease (CAD) is a leading cause of morbidity and mortality globally, with elevated homocysteine levels increasingly recognized as an independent risk factor. This meta-analysis aims to evaluate the relationship between homocysteine levels and CAD risk by pooling data from multiple studies.
Materials and Methods:
A comprehensive meta-analysis was conducted using data from 25 studies. Random-effects models were used to calculate pooled odds ratios (OR) and 95% confidence intervals (CI), accounting for heterogeneity among studies.
Results:
The pooled results showed a significant association between elevated homocysteine levels and increased risk of CAD, with a combined OR indicating a moderate but consistent effect size across studies.
Conclusion:
Elevated homocysteine levels are significantly associated with an increased risk of CAD. These findings support the incorporation of homocysteine measurement into cardiovascular risk assessment protocols. |
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| ISSN: | 0976-4879 0975-7406 |