LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. DNA hypomethylation, particularly of Long Interspersed Nuclear Element-1 (LINE-1) repetitive sequences, has been implicated in CRC development and progression. The purpose of this meta-analysis and systematic review wa...
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Elsevier
2025-02-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402500790X |
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| author | Akbar Bagheri Tohid Jafari-Koshki Leila Alizadeh Mortaza Raeisi Yaghoub Moaddab Abbas Karimi |
| author_facet | Akbar Bagheri Tohid Jafari-Koshki Leila Alizadeh Mortaza Raeisi Yaghoub Moaddab Abbas Karimi |
| author_sort | Akbar Bagheri |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. DNA hypomethylation, particularly of Long Interspersed Nuclear Element-1 (LINE-1) repetitive sequences, has been implicated in CRC development and progression. The purpose of this meta-analysis and systematic review was to evaluate the prognostic value of LINE-1 methylation level in patients with CRC. Relevant studies were identified through systematic database searches, and summary hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated for relations between LINE-1 hypomethylation and overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The current systematic review protocol was registered on International Prospective Register of Systematic Reviews (PROSPERO, CRD42024496615). A total of 19 studies comprising 8169 CRC patients were included. The pooled analysis showed no significant association between LINE-1 hypomethylation and OS in the overall population (HR = 1.70, 95 % CI: 0.97–2.96). However, in stage II/III patients, LINE-1 hypomethylation was significantly associated with poorer OS (HR = 1.92, 95 % CI: 1.26–2.91) and DFS (HR = 2.81, 95 % CI: 1.33–5.93). No significant association was found between LINE-1 hypomethylation and CSS (HR = 1.39, 95 % CI: 0.68–2.83). Substantial heterogeneity was observed across studies. The study suggests that LINE-1 methylation level could be a valuable prognostic biomarker for advanced-stage CRC patients, potentially improving personalized care and highlighting areas for future research to establish standardized methodologies. |
| format | Article |
| id | doaj-art-ef16d904c68c4361baced984d6b4091e |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ef16d904c68c4361baced984d6b4091e2025-02-08T05:00:43ZengElsevierHeliyon2405-84402025-02-01113e42410LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysisAkbar Bagheri0Tohid Jafari-Koshki1Leila Alizadeh2Mortaza Raeisi3Yaghoub Moaddab4Abbas Karimi5Department of Molecular Medicine, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranMolecular Medicine Research Center (MMRC), Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, IranGastroenterology and Liver Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranHematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, IranGastroenterology and Liver Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Molecular Medicine, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author. Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences. Golgasht St., Tabriz, East Azerbaijan, 5166614756, Iran.Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. DNA hypomethylation, particularly of Long Interspersed Nuclear Element-1 (LINE-1) repetitive sequences, has been implicated in CRC development and progression. The purpose of this meta-analysis and systematic review was to evaluate the prognostic value of LINE-1 methylation level in patients with CRC. Relevant studies were identified through systematic database searches, and summary hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated for relations between LINE-1 hypomethylation and overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The current systematic review protocol was registered on International Prospective Register of Systematic Reviews (PROSPERO, CRD42024496615). A total of 19 studies comprising 8169 CRC patients were included. The pooled analysis showed no significant association between LINE-1 hypomethylation and OS in the overall population (HR = 1.70, 95 % CI: 0.97–2.96). However, in stage II/III patients, LINE-1 hypomethylation was significantly associated with poorer OS (HR = 1.92, 95 % CI: 1.26–2.91) and DFS (HR = 2.81, 95 % CI: 1.33–5.93). No significant association was found between LINE-1 hypomethylation and CSS (HR = 1.39, 95 % CI: 0.68–2.83). Substantial heterogeneity was observed across studies. The study suggests that LINE-1 methylation level could be a valuable prognostic biomarker for advanced-stage CRC patients, potentially improving personalized care and highlighting areas for future research to establish standardized methodologies.http://www.sciencedirect.com/science/article/pii/S240584402500790XColorectal cancerLong interspersed nuclear element-1MethylationSurvival |
| spellingShingle | Akbar Bagheri Tohid Jafari-Koshki Leila Alizadeh Mortaza Raeisi Yaghoub Moaddab Abbas Karimi LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis Heliyon Colorectal cancer Long interspersed nuclear element-1 Methylation Survival |
| title | LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis |
| title_full | LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis |
| title_fullStr | LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis |
| title_full_unstemmed | LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis |
| title_short | LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis |
| title_sort | line 1 methylation status and survival outcomes in colorectal cancer patients a systematic review and meta analysis |
| topic | Colorectal cancer Long interspersed nuclear element-1 Methylation Survival |
| url | http://www.sciencedirect.com/science/article/pii/S240584402500790X |
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