Anti-CTGF/PD-1 bispecific antibody Y126S restrains desmoplastic and immunosuppressive microenvironment in pancreatic cancer

Anti-CTGF/PD-1 bispecific antibody Y126S restrains desmoplastic and immunosuppressive microenvironment in pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic and immunosuppressive tumor microenvironment (TME), limiting the efficacy of immune checkpoint inhibitors such as anti-programmed cell death 1 (PD-1).Methods This study aimed to evaluate the therapeutic potential o...

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Bibliographic Details
Main Authors:	Wei Chen, Hai Huang, Wang Peng, Jingwen Liang, Shiru Chen, Yuchong Zhao, Mengdie Cao, Yilei Yang, Shuya Bai, Qiaodan Zhou, Jiamei Jiang, Yilin Gu, Ronghua Wang, Bin Cheng
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-06-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/13/6/e012144.full
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