Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male rats
Acrylamide (ACR) is a toxic chemical found in food and the environment. Medicinal traditional plants are used as alternatives to attenuate the adverse effects of many hazardous chemicals on human health. This study investigated the protective effects of prepared traditional aqueous extract of aeria...
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Society of Land Measurements and Cadastre from Transylvania (SMTCT)
2025-06-01
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| Series: | Notulae Scientia Biologicae |
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| Online Access: | https://www.notulaebiologicae.ro/index.php/nsb/article/view/12522 |
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| author | Farida DAOUDI Djahida MAHDI Leila BEDDAR |
| author_facet | Farida DAOUDI Djahida MAHDI Leila BEDDAR |
| author_sort | Farida DAOUDI |
| collection | DOAJ |
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Acrylamide (ACR) is a toxic chemical found in food and the environment. Medicinal traditional plants are used as alternatives to attenuate the adverse effects of many hazardous chemicals on human health. This study investigated the protective effects of prepared traditional aqueous extract of aerial parts of Teucrium polium L. (T. polium) on ACR-induced thyro-reprotoxicityin male rats. In this study, 24 rats were distributed into four equal groups and treated orally for 21 days. The first group was the control; the second and third groups received ACR (20 mg/kg/bw) and T. polium (400 mg/kg/bw), respectively; and the fourth group received T. polium and ACR. ACR caused a significant decrease in daily body weight and no changes in testes and epididymis relative weights. Compared to controls, ACR triggered hypothyroidism, as shown by a significant decrease in triiodothyronine and thyroxine plasma levels and thyroid histopathology. Most of thyroid follicles were hypertrophied; other follicles degenerated, and their form changed with the absence of colloid and fusion of the follicles, while others appeared with multiple layers that obliterated the lumen, and others were infiltrated by inflammatory cells. Moreover, ACR caused atrophy and severe degeneration in both seminiferous and epididymal tubules. The majority of these tubules were empty and devoid of spermatozoa. ACR also significantly decreased testosterone levels, sperm concentration, motility, and vitality. However, all deleterious effects of ACR were ameliorated following the administration of T. polium. The aerial parts of aqueous extract of T. polium provide substantial protection against ACR-induced thyro-reprotoxicity, thus improving male fertility and reproduction.
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| format | Article |
| id | doaj-art-ef106e92a34a4274b940d72c836940c4 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-06-01 |
| publisher | Society of Land Measurements and Cadastre from Transylvania (SMTCT) |
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| series | Notulae Scientia Biologicae |
| spelling | doaj-art-ef106e92a34a4274b940d72c836940c42025-08-20T03:31:10ZengSociety of Land Measurements and Cadastre from Transylvania (SMTCT)Notulae Scientia Biologicae2067-32642025-06-0117210.55779/nsb17212522Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male ratsFarida DAOUDI0Djahida MAHDI1Leila BEDDAR2University of Oum-El-Bouaghi, Faculty of Exact Sciences and Nature and Life Sciences, Department of Nature and Life Sciences, Laboratory of Natural Resources and Management of Sensitive Environments ‘RNAMS’, Oum-El-Bouaghi, 04000University of Oum El Bouaghi, Faculty of Exact Sciences and Nature and Life Sciences, Department of Nature and Life Sciences, Oum El Bouaghi, 04000; Badji Mokhtar University, Faculty of Sciences, Department of Biology, Laboratory of Animal Eco-Physiology, Annaba, 23000Scientific Research Laboratory of Molecular Biology and Genetics, Faculty of Medicine, Constantine University 3, Constantine, 25000, Algeria Acrylamide (ACR) is a toxic chemical found in food and the environment. Medicinal traditional plants are used as alternatives to attenuate the adverse effects of many hazardous chemicals on human health. This study investigated the protective effects of prepared traditional aqueous extract of aerial parts of Teucrium polium L. (T. polium) on ACR-induced thyro-reprotoxicityin male rats. In this study, 24 rats were distributed into four equal groups and treated orally for 21 days. The first group was the control; the second and third groups received ACR (20 mg/kg/bw) and T. polium (400 mg/kg/bw), respectively; and the fourth group received T. polium and ACR. ACR caused a significant decrease in daily body weight and no changes in testes and epididymis relative weights. Compared to controls, ACR triggered hypothyroidism, as shown by a significant decrease in triiodothyronine and thyroxine plasma levels and thyroid histopathology. Most of thyroid follicles were hypertrophied; other follicles degenerated, and their form changed with the absence of colloid and fusion of the follicles, while others appeared with multiple layers that obliterated the lumen, and others were infiltrated by inflammatory cells. Moreover, ACR caused atrophy and severe degeneration in both seminiferous and epididymal tubules. The majority of these tubules were empty and devoid of spermatozoa. ACR also significantly decreased testosterone levels, sperm concentration, motility, and vitality. However, all deleterious effects of ACR were ameliorated following the administration of T. polium. The aerial parts of aqueous extract of T. polium provide substantial protection against ACR-induced thyro-reprotoxicity, thus improving male fertility and reproduction. https://www.notulaebiologicae.ro/index.php/nsb/article/view/12522acrylamide; histopathology study; Jaada; repro-hormones; sperm parameters; testis; thyroid gland |
| spellingShingle | Farida DAOUDI Djahida MAHDI Leila BEDDAR Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male rats Notulae Scientia Biologicae acrylamide; histopathology study; Jaada; repro-hormones; sperm parameters; testis; thyroid gland |
| title | Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male rats |
| title_full | Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male rats |
| title_fullStr | Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male rats |
| title_full_unstemmed | Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male rats |
| title_short | Therapeutic effects of aqueous extract of aerial parts of Teucrium polium L. against acrylamide-induced thyro-reprotoxicity in male rats |
| title_sort | therapeutic effects of aqueous extract of aerial parts of teucrium polium l against acrylamide induced thyro reprotoxicity in male rats |
| topic | acrylamide; histopathology study; Jaada; repro-hormones; sperm parameters; testis; thyroid gland |
| url | https://www.notulaebiologicae.ro/index.php/nsb/article/view/12522 |
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