Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care Units
<i>Staphylococcus aureus</i> infections are an important cause of morbidity and mortality among patients in intensive care units (ICUs), particularly those with multiple comorbidities and critical conditions. Methicillin-resistant <i>S. aureus</i> (MRSA) and methicillin-sensi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/7/1519 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849733926838337536 |
|---|---|
| author | Gustavo Andrés Urriago-Osorio Heiler Lozada-Ramos Jorge Enrique Daza-Arana Paola Andrea Ruiz-Jiménez Giovanna Patricia Rivas-Tafurt Diana Marcela Bonilla-Bonilla |
| author_facet | Gustavo Andrés Urriago-Osorio Heiler Lozada-Ramos Jorge Enrique Daza-Arana Paola Andrea Ruiz-Jiménez Giovanna Patricia Rivas-Tafurt Diana Marcela Bonilla-Bonilla |
| author_sort | Gustavo Andrés Urriago-Osorio |
| collection | DOAJ |
| description | <i>Staphylococcus aureus</i> infections are an important cause of morbidity and mortality among patients in intensive care units (ICUs), particularly those with multiple comorbidities and critical conditions. Methicillin-resistant <i>S. aureus</i> (MRSA) and methicillin-sensitive <i>S. aureus</i> (MSSA) strains differ in resistance, clinical behavior, and prognoses, making it important to understand their effects on clinical outcomes. Comparing clinical outcomes of MRSA and MSSA infections is important. This retrospective cohort study analyzed ICU patients with confirmed <i>S. aureus</i> infections at a quaternary care hospital. Demographic, clinical, and comorbidity data were collected. Poisson regression was used to analyze 7-day mortality and identify adjusted risk factors. Seven-day mortality was higher in patients with MSSA than MRSA infections, with an adjusted relative risk for MRSA of 0.380 (95% confidence interval: 0.15–0.95; <i>p</i> = 0.039). Independent risk factors for mortality included lack of an infectious disease consultation, vascular comorbidities, such as peripheral vascular disease and cerebrovascular events, chronic kidney disease, and inotropic support requirement. Patients with MRSA infections required significantly longer ventilatory support (mean 43.5 days vs. 13 days for MSSA; <i>p</i> = 0.019). <i>Staphylococcus aureus</i> infections in ICU patients were associated with poor outcomes, particularly in patients without infectious disease consultation and those with vascular comorbidities. Mortality differences between MRSA and MSSA highlight the importance of appropriate empiric therapy and standardized protocols incorporating infectious disease consultation to improve outcomes in critically ill patients. |
| format | Article |
| id | doaj-art-ef0f5b970ac249b982569dcddf91ea21 |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-ef0f5b970ac249b982569dcddf91ea212025-08-20T03:07:55ZengMDPI AGMicroorganisms2076-26072025-06-01137151910.3390/microorganisms13071519Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care UnitsGustavo Andrés Urriago-Osorio0Heiler Lozada-Ramos1Jorge Enrique Daza-Arana2Paola Andrea Ruiz-Jiménez3Giovanna Patricia Rivas-Tafurt4Diana Marcela Bonilla-Bonilla5Internal Medicine Specialization Program, Department of Health, Universidad Santiago de Cali, Santiago de Cali 760035, ColombiaInternal Medicine Specialization Program, Department of Health, Universidad Santiago de Cali, Santiago de Cali 760035, ColombiaInternal Medicine Specialization Program, Department of Health, Universidad Santiago de Cali, Santiago de Cali 760035, ColombiaInternal Medicine Specialization Program, Department of Health, Universidad Santiago de Cali, Santiago de Cali 760035, ColombiaInternal Medicine Specialization Program, Department of Health, Universidad Santiago de Cali, Santiago de Cali 760035, ColombiaInternal Medicine Specialization Program, Department of Health, Universidad Santiago de Cali, Santiago de Cali 760035, Colombia<i>Staphylococcus aureus</i> infections are an important cause of morbidity and mortality among patients in intensive care units (ICUs), particularly those with multiple comorbidities and critical conditions. Methicillin-resistant <i>S. aureus</i> (MRSA) and methicillin-sensitive <i>S. aureus</i> (MSSA) strains differ in resistance, clinical behavior, and prognoses, making it important to understand their effects on clinical outcomes. Comparing clinical outcomes of MRSA and MSSA infections is important. This retrospective cohort study analyzed ICU patients with confirmed <i>S. aureus</i> infections at a quaternary care hospital. Demographic, clinical, and comorbidity data were collected. Poisson regression was used to analyze 7-day mortality and identify adjusted risk factors. Seven-day mortality was higher in patients with MSSA than MRSA infections, with an adjusted relative risk for MRSA of 0.380 (95% confidence interval: 0.15–0.95; <i>p</i> = 0.039). Independent risk factors for mortality included lack of an infectious disease consultation, vascular comorbidities, such as peripheral vascular disease and cerebrovascular events, chronic kidney disease, and inotropic support requirement. Patients with MRSA infections required significantly longer ventilatory support (mean 43.5 days vs. 13 days for MSSA; <i>p</i> = 0.019). <i>Staphylococcus aureus</i> infections in ICU patients were associated with poor outcomes, particularly in patients without infectious disease consultation and those with vascular comorbidities. Mortality differences between MRSA and MSSA highlight the importance of appropriate empiric therapy and standardized protocols incorporating infectious disease consultation to improve outcomes in critically ill patients.https://www.mdpi.com/2076-2607/13/7/1519<i>Staphylococcus aureus</i>MRSAMSSAmortality |
| spellingShingle | Gustavo Andrés Urriago-Osorio Heiler Lozada-Ramos Jorge Enrique Daza-Arana Paola Andrea Ruiz-Jiménez Giovanna Patricia Rivas-Tafurt Diana Marcela Bonilla-Bonilla Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care Units Microorganisms <i>Staphylococcus aureus</i> MRSA MSSA mortality |
| title | Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care Units |
| title_full | Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care Units |
| title_fullStr | Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care Units |
| title_full_unstemmed | Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care Units |
| title_short | Comparison of Clinical Characteristics and Outcomes Between MRSA and MSSA Infections Among Patients in Intensive Care Units |
| title_sort | comparison of clinical characteristics and outcomes between mrsa and mssa infections among patients in intensive care units |
| topic | <i>Staphylococcus aureus</i> MRSA MSSA mortality |
| url | https://www.mdpi.com/2076-2607/13/7/1519 |
| work_keys_str_mv | AT gustavoandresurriagoosorio comparisonofclinicalcharacteristicsandoutcomesbetweenmrsaandmssainfectionsamongpatientsinintensivecareunits AT heilerlozadaramos comparisonofclinicalcharacteristicsandoutcomesbetweenmrsaandmssainfectionsamongpatientsinintensivecareunits AT jorgeenriquedazaarana comparisonofclinicalcharacteristicsandoutcomesbetweenmrsaandmssainfectionsamongpatientsinintensivecareunits AT paolaandrearuizjimenez comparisonofclinicalcharacteristicsandoutcomesbetweenmrsaandmssainfectionsamongpatientsinintensivecareunits AT giovannapatriciarivastafurt comparisonofclinicalcharacteristicsandoutcomesbetweenmrsaandmssainfectionsamongpatientsinintensivecareunits AT dianamarcelabonillabonilla comparisonofclinicalcharacteristicsandoutcomesbetweenmrsaandmssainfectionsamongpatientsinintensivecareunits |